Universität zu Köln

Papadopoulos, Christodoulos E., Pagourelias, Efstathios ORCID: 0000-0003-0189-8353, Bakogiannis, Constantinos, Triantafyllou, Konstantinos, Baltoumas, Konstantinos, Kassimatis, Efstratios, Zioutas, Dimitrios, Siskos, Dimitrios, Tzikas, Stergios ORCID: 0000-0002-7811-5620, Fragakis, Nikolaos, Papagianni, Aikaterini and Vassilikos, Vassilios (2018). Left atrial deformation as a potent predictor for paroxysmal atrial fibrillation in patients with end-stage renal disease. Int. J. Cardiovasc. Imaging, 34 (9). S. 1393 - 1402. DORDRECHT: SPRINGER. ISSN 1573-0743

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Abstract

It is widely known that various factors contribute to left atrial (LA) mechanical dysfunction in patients with end stage renal disease (ESRD). However, the connection between atrial dysfunction and arrhythmic events such as paroxysmal atrial fibrillation (PAF), in this group of patients, remains unclear. The purpose of our study was to evaluate prospectively the association between LA deformation indices and PAF in ESRD patients. 79 patients (41 men, mean age 57 +/- 17) with ESRD and preserved left ventricular systolic function comprised the study population. All patients underwent a baseline comprehensive echocardiography study and were followed for a mean period of 16 +/- 5 months. PAF episodes, first and the following events, were reported. LA longitudinal strain reflecting LA reservoir function and LA longitudinal strain rate reflecting LA pump function were specifically evaluated as LA deformation indices of interest, using 2D speckle tracking echocardiography. At the end of follow up period nine patients died. 15 of the rest 70 reported one or more episodes of PAF. LA indexed volumes were significantly higher in patients with PAF (32 +/- 26 vs. 21.5 +/- 9 ml/m(2), p = 0.002), mean LA strain was significantly reduced (17 +/- 7 vs. 27 +/- 9%, p < 0.001) as well as mean LA stain rate (-1.19 +/- 0.5 vs. -1.95 +/- 0.5 1/s, p < 0.001). Multivariate analysis showed that LA strain rate when adjusted with age together with PAF history remained the single most significant echocardiographic parameter for PAF prediction. Impaired LA strain and LA strain rate are associated with PAF in ESRD patients. LA strain rate might be a better independent predictor of PAF, compared to standard echocardiographic indices. Further prospective studies are needed to validate its relevance in routine clinical practice.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Papadopoulos, Christodoulos E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pagourelias, Efstathios UNSPECIFIED orcid.org/0000-0003-0189-8353 UNSPECIFIED Bakogiannis, Constantinos UNSPECIFIED UNSPECIFIED UNSPECIFIED Triantafyllou, Konstantinos UNSPECIFIED UNSPECIFIED UNSPECIFIED Baltoumas, Konstantinos UNSPECIFIED UNSPECIFIED UNSPECIFIED Kassimatis, Efstratios UNSPECIFIED UNSPECIFIED UNSPECIFIED Zioutas, Dimitrios UNSPECIFIED UNSPECIFIED UNSPECIFIED Siskos, Dimitrios UNSPECIFIED UNSPECIFIED UNSPECIFIED Tzikas, Stergios UNSPECIFIED orcid.org/0000-0002-7811-5620 UNSPECIFIED Fragakis, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED Papagianni, Aikaterini UNSPECIFIED UNSPECIFIED UNSPECIFIED Vassilikos, Vassilios UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-173659
DOI:	10.1007/s10554-018-1353-x
Journal or Publication Title:	Int. J. Cardiovasc. Imaging
Volume:	34
Number:	9
Page Range:	S. 1393 - 1402
Date:	2018
Publisher:	SPRINGER
Place of Publication:	DORDRECHT
ISSN:	1573-0743
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SPECKLE-TRACKING ECHOCARDIOGRAPHY; FIBROBLAST GROWTH FACTOR-23; CHRONIC KIDNEY-DISEASE; EUROPEAN ASSOCIATION; CHAMBER QUANTIFICATION; DIASTOLIC FUNCTION; CARDIAC MECHANICS; AMERICAN SOCIETY; HEART-FAILURE; RECOMMENDATIONS Multiple languages Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17365