Universität zu Köln

Lee, Jun-Hoe ORCID: 0000-0002-6331-3472, Lewis, Kevin M., Moural, Timothy W., Kirilenko, Bogdan, Borgonovo, Barbara, Prange, Gisa, Koessl, Manfred, Huggenberger, Stefan, Kang, ChulHee and Hiller, Michael ORCID: 0000-0003-3024-1449 (2018). Molecular parallelism in fast-twitch muscle proteins in echolocating mammals. Sci. Adv., 4 (9). WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 2375-2548

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Abstract

Detecting associations between genomic changes and phenotypic differences is fundamental to understanding how phenotypes evolved. By systematically screening for parallel amino acid substitutions, we detected known as well as novel cases (Strc, Tecta, and Cabp2) of parallelism between echolocating bats and toothed whales in proteins that could contribute to high-frequency hearing adaptations. Our screen also showed that echolocating mammals exhibit an unusually high number of parallel substitutions in fast-twitch muscle fiber proteins. Both echolocating bats and toothed whales produce an extremely rapid call rate when homing in on their prey, which was shown in bats to be powered by specialized superfast muscles. We show that these genes with parallel substitutions (Casq1, Atp2a1, Myh2, and Myl1) are expressed in the superfast sound-producing muscle of bats. Furthermore, we found that the calcium storage protein calsequestrin 1 of the little brown bat and the bottlenose dolphin functionally converged in its ability to form calcium-sequestering polymers at lower calcium concentrations, which may contribute to rapid calcium transients required for superfast muscle physiology. The proteins that our genomic screen detected could be involved in the convergent evolution of vocalization in echolocating mammals by potentially contributing to both rapid Ca2+ transients and increased shortening velocities in superfast muscles.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lee, Jun-Hoe UNSPECIFIED orcid.org/0000-0002-6331-3472 UNSPECIFIED Lewis, Kevin M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moural, Timothy W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirilenko, Bogdan UNSPECIFIED UNSPECIFIED UNSPECIFIED Borgonovo, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Prange, Gisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Koessl, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED Huggenberger, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Kang, ChulHee UNSPECIFIED UNSPECIFIED UNSPECIFIED Hiller, Michael UNSPECIFIED orcid.org/0000-0003-3024-1449 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-174107
DOI:	10.1126/sciadv.aat9660
Journal or Publication Title:	Sci. Adv.
Volume:	4
Number:	9
Date:	2018
Publisher:	AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication:	WASHINGTON
ISSN:	2375-2548
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEARING GENE PRESTIN; SKELETAL-MUSCLE; SARCOPLASMIC-RETICULUM; PHYLOGENETIC ANALYSIS; TECTORIAL MEMBRANE; SUPERFAST MUSCLES; HEAVY-CHAIN; CONVERGENCE; EVOLUTION; CALSEQUESTRIN Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17410