Universität zu Köln

Hellmann, Daniel M., Radojska, Stela, Fimmers, Rolf and Gathof, Birgit S. (2018). Probability of success in the search for a related bone marrow donor in Cologne, Germany using HLA-A, -B and-DRB1 haplotype frequencies. HLA, 92 (3). S. 154 - 160. HOBOKEN: WILEY. ISSN 2059-2310

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Abstract

Between 2004 and 2013, 603 patients and their relatives (n=1297) were typed as part of the search for a suitable HLA-matched donor in their nuclear and extended families at the central service provider for transfusion medicine at the University Hospital of Cologne. The high success rate in finding donors over the years at our center (38.1%) led us to examine our database retrospectively in order to evaluate the donor search and haplotype frequencies (HFs) in the sample. Our goal was to identify the factors contributing to this high success rate and also to compare the HFs we observed with other reported haplotype frequency estimations (HFE) for the Cologne area. Probability estimations for a successful donor search were constructed based on the HFEs for the sample.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hellmann, Daniel M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Radojska, Stela UNSPECIFIED UNSPECIFIED UNSPECIFIED Fimmers, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Gathof, Birgit S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-174498
DOI:	10.1111/tan.13356
Journal or Publication Title:	HLA
Volume:	92
Number:	3
Page Range:	S. 154 - 160
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	2059-2310
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MATCHED UNRELATED DONORS; EXTENDED FAMILIES; SIBLING DONORS; TRANSPLANTATION; REGISTRY; OUTCOMES; ALLELES Multiple languages Cell Biology; Immunology; Pathology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17449