Bohnenberger, Hanibal, Kaderali, Lars, Stroebel, Philipp, Yepes, Diego, Plessmann, Uwe, Dharia, Neekesh V., Yao, Sha, Heydt, Carina, Merkelbach-Bruse, Sabine, Emmert, Alexander, Hoffmann, Jonatan, Bodemeyer, Julius, Reuter-Jessen, Kirsten, Lois, Anna-Maria, Droege, Leif Hendrik, Baumeister, Philipp, Walz, Christoph, Biggemann, Lorenz, Walter, Roland, Haeupl, Bjoern, Comoglio, Federico, Pan, Kuan-Ting, Scheich, Sebastian, Lenz, Christof, Kueffer, Stefan, Bremmer, Felix, Kitz, Julia, Sitte, Maren, Beissbarth, Tim, Hinterthaner, Marc, Sebastian, Martin, Lotz, Joachim, Schildhaus, Hans-Ulrich, Wolff, Hendrik, Danner, Bernhard C., Brandts, Christian, Buettner, Reinhard, Canis, Martin, Stegmaier, Kimberly, Serve, Hubert, Urlaub, Henning and Oellerich, Thomas (2018). Comparative proteomics reveals a diagnostic signature for pulmonary head-and-neck cancermetastasis. EMBO Mol. Med., 10 (9). HOBOKEN: WILEY. ISSN 1757-4684

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Abstract

Patients with head-and-neck cancer can develop both lung metastasis and primary lung cancer during the course of their disease. Despite the clinical importance of discrimination, reliable diagnostic biomarkers are still lacking. Here, we have characterised a cohort of squamous cell lung (SQCLC) and head-and-neck (HNSCC) carcinomas by quantitative proteomics. In a training cohort, we quantified 4,957 proteins in 44 SQCLC and 30 HNSCC tumours. A total of 518 proteins were found to be differentially expressed between SQCLC and HNSCC, and some of these were identified as genetic dependencies in either of the two tumour types. Using supervised machine learning, we inferred a proteomic signature for the classification of squamous cell carcinomas as either SQCLCor HNSCC, with diagnostic accuracies of 90.5% and 86.8% in cross- and independent validations, respectively. Furthermore, application of this signature to a cohort of pulmonary squamous cell carcinomas of unknown origin leads to a significant prognosticseparation. This study not only provides a diagnostic proteomicsignature for classification of secondary lung tumours in HNSCC patients, but also represents a proteomic resource for HNSCC andSQCLC.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bohnenberger, HanibalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaderali, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stroebel, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yepes, DiegoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plessmann, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dharia, Neekesh V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yao, ShaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heydt, CarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Merkelbach-Bruse, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Emmert, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffmann, JonatanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bodemeyer, JuliusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reuter-Jessen, KirstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lois, Anna-MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Droege, Leif HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baumeister, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walz, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biggemann, LorenzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walter, RolandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haeupl, BjoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Comoglio, FedericoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pan, Kuan-TingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheich, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lenz, ChristofUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kueffer, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bremmer, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kitz, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sitte, MarenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beissbarth, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hinterthaner, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sebastian, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lotz, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schildhaus, Hans-UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolff, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Danner, Bernhard C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brandts, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buettner, ReinhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Canis, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stegmaier, KimberlyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Serve, HubertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Urlaub, HenningUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oellerich, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-174671
DOI: 10.15252/emmm.201708428
Journal or Publication Title: EMBO Mol. Med.
Volume: 10
Number: 9
Date: 2018
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1757-4684
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SQUAMOUS-CELL CARCINOMA; COMPREHENSIVE GENOMIC CHARACTERIZATION; DISTANT METASTASES; LUNG-CANCER; DIFFERENTIAL-DIAGNOSIS; TUMORS; CISPLATIN; RISKMultiple languages
Medicine, Research & ExperimentalMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/17467

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