Universität zu Köln

Singh, Karmveer, Camera, Emanuela ORCID: 0000-0001-6633-0449, Krug, Linda, Basu, Abhijit, Pandey, Rajeev Kumar, Munir, Saira, Wlaschek, Meinhard, Kochanek, Stefan, Schorpp-Kistner, Marina, Picardo, Mauro ORCID: 0000-0003-4899-6639, Angel, Peter, Niemann, Catherin, Maity, Pallab ORCID: 0000-0001-9769-3533 and Scharffetter-Kochanek, Karin (2018). JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin. Nat. Commun., 9. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

Transcription factors ensure skin homeostasis via tight regulation of distinct resident stem cells. Here we report that JunB, a member of the AP-1 transcription factor family, regulates epidermal stem cells and sebaceous glands through balancing proliferation and differentiation of progenitors and by suppressing lineage infidelity. JunB deficiency in basal progenitors results in a dermatitis-like syndrome resembling seborrheic dermatitis harboring structurally and functionally impaired sebaceous glands with a globally altered lipid profile. A fate switch occurs in a subset of JunB deficient epidermal progenitors during wound healing resulting in de novo formation of sebaceous glands. Dysregulated Notch signaling is identified to be causal for this phenotype. In fact, pharmacological inhibition of Notch signaling can efficiently restore the lineage drift, impaired epidermal differentiation and disrupted barrier function in JunB conditional knockout mice. These findings define an unprecedented role for JunB in epidermal-pilosebaceous stem cell homeostasis and its pathology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Singh, Karmveer UNSPECIFIED UNSPECIFIED UNSPECIFIED Camera, Emanuela UNSPECIFIED orcid.org/0000-0001-6633-0449 UNSPECIFIED Krug, Linda UNSPECIFIED UNSPECIFIED UNSPECIFIED Basu, Abhijit UNSPECIFIED UNSPECIFIED UNSPECIFIED Pandey, Rajeev Kumar UNSPECIFIED UNSPECIFIED UNSPECIFIED Munir, Saira UNSPECIFIED UNSPECIFIED UNSPECIFIED Wlaschek, Meinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Kochanek, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Schorpp-Kistner, Marina UNSPECIFIED UNSPECIFIED UNSPECIFIED Picardo, Mauro UNSPECIFIED orcid.org/0000-0003-4899-6639 UNSPECIFIED Angel, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Niemann, Catherin UNSPECIFIED UNSPECIFIED UNSPECIFIED Maity, Pallab UNSPECIFIED orcid.org/0000-0001-9769-3533 UNSPECIFIED Scharffetter-Kochanek, Karin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-176066
DOI:	10.1038/s41467-018-05726-z
Journal or Publication Title:	Nat. Commun.
Volume:	9
Date:	2018
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BULGE STEM-CELLS; SEBORRHEIC DERMATITIS; SELF-RENEWAL; HAIR; DIFFERENTIATION; ACTIVATION; PROTEINS; PROLIFERATION; EXPRESSION; MOUSE Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17606