Ghadri, Jelena R., Kato, Ken ORCID: 0000-0001-6993-5152, Cammann, Victoria L., Gili, Sebastiano, Jurisic, Stjepan, Di Vece, Davide, Candreva, Alessandro, Ding, Katharina J., Micek, Jozef, Szawan, Konrad A., Bacchi, Beatrice, Bianchi, Rahel, Levinson, Rena A., Wischnewsky, Manfred, Seifert, Burkhardt ORCID: 0000-0002-5829-2478, Schlossbauer, Susanne A., Citro, Rodolfo, Bossone, Eduardo, Muenzel, Thomas, Knorr, Maike, Heiner, Susanne, D'Ascenzo, Fabrizio ORCID: 0000-0002-6646-9317, Franke, Jennifer, Sarcon, Annahita, Napp, L. Christian ORCID: 0000-0001-9945-0842, Jaguszewski, Milosz ORCID: 0000-0002-2555-593X, Noutsias, Michel, Katus, Hugo A., Burgdorf, Christof, Schunkert, Heribert, Thiele, Holger, Bauersachs, Johann, Tschoepe, Carsten, Pieske, Burkert M., Rajan, Lawrence, Michels, Guido, Pfister, Roman, Cuneo, Alessandro, Jacobshagen, Claudius, Hasenfuss, Gerd, Karakas, Mahir, Koenig, Wolfgang, Rottbauer, Wolfgang, Said, Samir M., Braun-Dullaeus, Ruediger C., Banning, Adrian ORCID: 0000-0002-2842-7861, Cuculi, Florim, Kobza, Richard, Fischer, Thomas A., Vasankari, Tuija, Airaksinen, K. E. Juhani, Opolski, Grzegorz, Dworakowski, Rafal, MacCarthy, Philip, Kaiser, Christoph, Osswald, Stefan ORCID: 0000-0002-9240-6731, Galiuto, Leonarda, Crea, Filippo, Dichtl, Wolfgang ORCID: 0000-0002-0421-2110, Empen, Klaus, Felix, Stephan B., Delmas, Clement ORCID: 0000-0001-9180-9128, Lairez, Olivier, El-Battrawy, Ibrahim, Akin, Ibrahim, Borggrefe, Martin, Horowitz, John ORCID: 0000-0001-6883-0703, Kozel, Martin ORCID: 0000-0001-6355-6370, Tousek, Petr, Widimsky, Petr, Gilyarova, Ekaterina, Shilova, Alexandra, Gilyarov, Mikhail, Winchester, David E., Ukena, Christian, Bax, Jeroen J., Prasad, Abhiram, Boehm, Michael, Luscher, Thomas F., Ruschitzka, Frank and Templin, Christian (2018). Long-Term Prognosis of Patients With Takotsubo Syndrome. J. Am. Coll. Cardiol., 72 (8). S. 874 - 883. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1558-3597

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Abstract

BACKGROUND Prognosis of Takotsubo syndrome (TTS) remains controversial due to scarcity of available data. Additionally, the effect of the triggering factors remains elusive. OBJECTIVES This study compared prognosis between TTS and acute coronary syndrome (ACS) patients and investigated short- and long-term outcomes in TTS based on different triggers. METHODS Patients with TTS were enrolled from the International Takotsubo Registry. Long-term mortality of patients with TTS was compared to an age- and sex-matched cohort of patients with ACS. In addition, short- and long-term outcomes were compared between different groups according to triggering conditions. RESULTS Overall, TTS patients had a comparable long-term mortality risk with ACS patients. Of 1,613 TTS patients, an emotional trigger was detected in 485 patients (30%). Of 630 patients (39%) related to physical triggers, 98 patients (6%) had acute neurologic disorders, while in the other 532 patients (33%), physical activities, medical conditions, or procedures were the triggering conditions. The remaining 498 patients (31%) had no identifiable trigger. TTS patients related to physical stress showed higher mortality rates than ACS patients during long-term follow-up, whereas patients related to emotional stress had better outcomes compared with ACS patients. CONCLUSIONS Overall, TTS patients had long-term outcomes comparable to age- and sex-matched ACS patients. Also, we demonstrated that TTS can either be benign or a life-threating condition depending on the inciting stress factor. We propose a new classification based on triggers, which can serve as a clinical tool to predict short- and long-term outcomes of TTS. (C) 2018 by the American College of Cardiology Foundation.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ghadri, Jelena R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kato, KenUNSPECIFIEDorcid.org/0000-0001-6993-5152UNSPECIFIED
Cammann, Victoria L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gili, SebastianoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jurisic, StjepanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Di Vece, DavideUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Candreva, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ding, Katharina J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Micek, JozefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szawan, Konrad A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bacchi, BeatriceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bianchi, RahelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Levinson, Rena A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wischnewsky, ManfredUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seifert, BurkhardtUNSPECIFIEDorcid.org/0000-0002-5829-2478UNSPECIFIED
Schlossbauer, Susanne A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Citro, RodolfoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bossone, EduardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muenzel, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knorr, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heiner, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
D'Ascenzo, FabrizioUNSPECIFIEDorcid.org/0000-0002-6646-9317UNSPECIFIED
Franke, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarcon, AnnahitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Napp, L. ChristianUNSPECIFIEDorcid.org/0000-0001-9945-0842UNSPECIFIED
Jaguszewski, MiloszUNSPECIFIEDorcid.org/0000-0002-2555-593XUNSPECIFIED
Noutsias, MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katus, Hugo A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burgdorf, ChristofUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schunkert, HeribertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thiele, HolgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauersachs, JohannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tschoepe, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pieske, Burkert M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rajan, LawrenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michels, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfister, RomanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuneo, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jacobshagen, ClaudiusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hasenfuss, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karakas, MahirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rottbauer, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Said, Samir M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braun-Dullaeus, Ruediger C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Banning, AdrianUNSPECIFIEDorcid.org/0000-0002-2842-7861UNSPECIFIED
Cuculi, FlorimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kobza, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, Thomas A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vasankari, TuijaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Airaksinen, K. E. JuhaniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Opolski, GrzegorzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dworakowski, RafalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
MacCarthy, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osswald, StefanUNSPECIFIEDorcid.org/0000-0002-9240-6731UNSPECIFIED
Galiuto, LeonardaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crea, FilippoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dichtl, WolfgangUNSPECIFIEDorcid.org/0000-0002-0421-2110UNSPECIFIED
Empen, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Felix, Stephan B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delmas, ClementUNSPECIFIEDorcid.org/0000-0001-9180-9128UNSPECIFIED
Lairez, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
El-Battrawy, IbrahimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akin, IbrahimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borggrefe, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horowitz, JohnUNSPECIFIEDorcid.org/0000-0001-6883-0703UNSPECIFIED
Kozel, MartinUNSPECIFIEDorcid.org/0000-0001-6355-6370UNSPECIFIED
Tousek, PetrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Widimsky, PetrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gilyarova, EkaterinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shilova, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gilyarov, MikhailUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winchester, David E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ukena, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bax, Jeroen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prasad, AbhiramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boehm, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luscher, Thomas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruschitzka, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Templin, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-176162
DOI: 10.1016/j.jacc.2018.06.016
Journal or Publication Title: J. Am. Coll. Cardiol.
Volume: 72
Number: 8
Page Range: S. 874 - 883
Date: 2018
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1558-3597
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CLINICAL-FEATURES; TAKO-TSUBO; MORTALITY; STRESS; CARDIOMYOPATHY; OUTCOMES; PROFILEMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/17616

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