Universität zu Köln

Dreher, Lena-Sophie and Hoppe, Thorsten ORCID: 0000-0002-4734-9352 (2018). ERADicate Tumor Progression with Metformin. Mol. Cell, 71 (4). S. 481 - 483. CAMBRIDGE: CELL PRESS. ISSN 1097-4164

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Abstract

Endoplasmic reticulum-associated degradation (ERAD) plays a crucial role in turnover of defective secretory proteins to maintain protein homeostasis. Cha et al. (2018) revealed that the anti-diabetic drug metformin induces ERAD of programmed death ligand (PD-L1), which attenuates tumor growth.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dreher, Lena-Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoppe, Thorsten UNSPECIFIED orcid.org/0000-0002-4734-9352 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-176376
DOI:	10.1016/j.molcel.2018.08.001
Journal or Publication Title:	Mol. Cell
Volume:	71
Number:	4
Page Range:	S. 481 - 483
Date:	2018
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1097-4164
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MECHANISM Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17637