Shroff, Rukshana, Bayazit, Aysun, Stefanidis, Constantinos J., Askiti, Varvara, Azukaitis, Karolis, Canpolat, Nur ORCID: 0000-0002-3420-9756, Agbas, Ayse ORCID: 0000-0002-3658-8622, Anarat, Ali, Aoun, Bilal, Bakkaloglu, Sevcan, Bhowruth, Devina, Borzych-Duzalka, Dagmara, Bulut, Ipek Kaplan, Buescher, Rainer, Dempster, Claire, Duzova, Ali, Habbig, Sandra, Hayes, Wesley, Hegde, Shivram, Krid, Saoussen, Licht, Christoph, Litwin, Mieczyslaw ORCID: 0000-0002-5241-2483, Mayes, Mark, Mir, Sevgi, Nemec, Rose, Obrycki, Lukasz ORCID: 0000-0002-5134-8643, Paglialonga, Fabio, Picca, Stefano, Ranchin, Bruno, Samaille, Charlotte, Shenoy, Mohan, Sinha, Manish, Smith, Colette ORCID: 0000-0003-2847-3355, Spasojevic, Brankica, Vidal, Enrico, Vondrak, Karel, Yilmaz, Alev, Zaloszyc, Ariane, Fischbach, Michel, Schaefer, Franz and Schmitt, Claus Peter (2018). Effect of haemodiafiltration vs conventional haemodialysis on growth and cardiovascular outcomes in children - the HDF, heart and height (3H) study. BMC Nephrol., 19. LONDON: BMC. ISSN 1471-2369

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Abstract

Background: Cardiovascular disease is prevalent in children on dialysis and accounts for almost 30% of all deaths. Randomised trials in adults suggest that haemodiafiltration (HDF) with high convection volumes is associated with reduced cardiovascular mortality compared to high-flux haemodialysis (HD); however paediatric data are scarce. We designed the haemodiafiltration, heart and height (3H) study to test the hypothesis that children on HDF have an improved cardiovascular risk profile, growth and nutritional status and quality of life, compared to those on conventional HD. We performed a non-randomised parallel-arm intervention study within the International Paediatric Haemodialysis Network Registry comparing children on HDF and conventional HD to determine annualised change in cardiovascular end-points and growth. Here we present the 3H study design and baseline characteristics of the study population. Methods: 190 children were screened and 177 (106 on HD and 71 on HDF) recruited from 28 centres in 10 countries. There was no difference in age, underlying diagnosis, comorbidities, previous dialysis therapy, dialysis vintage, residual renal function, type of vascular access or blood flow between HD and HDF groups. High flux dialysers were used in 63% of HD patients and ultra-pure water was available in 52%. HDF patients achieved a median convection volume of 13.3 L/m(2); this was associated with the blood flow rate only ((p = 0.0004, r = 0.42) and independent of access type (p = 038). Discussion: This is the largest study on dialysis outcomes in children that involves deep phenotyping across a wide range of cardiovascular, anthropometric, nutritional and health-related quality of life measures, to test the hypothesis that HDF leads to improved cardiovascular and growth outcomes compared to conventional HD.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Shroff, RukshanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bayazit, AysunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stefanidis, Constantinos J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Askiti, VarvaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Azukaitis, KarolisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Canpolat, NurUNSPECIFIEDorcid.org/0000-0002-3420-9756UNSPECIFIED
Agbas, AyseUNSPECIFIEDorcid.org/0000-0002-3658-8622UNSPECIFIED
Anarat, AliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aoun, BilalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bakkaloglu, SevcanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bhowruth, DevinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borzych-Duzalka, DagmaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bulut, Ipek KaplanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buescher, RainerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dempster, ClaireUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duzova, AliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Habbig, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hayes, WesleyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hegde, ShivramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krid, SaoussenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Licht, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Litwin, MieczyslawUNSPECIFIEDorcid.org/0000-0002-5241-2483UNSPECIFIED
Mayes, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mir, SevgiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nemec, RoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obrycki, LukaszUNSPECIFIEDorcid.org/0000-0002-5134-8643UNSPECIFIED
Paglialonga, FabioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Picca, StefanoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ranchin, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Samaille, CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shenoy, MohanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sinha, ManishUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, ColetteUNSPECIFIEDorcid.org/0000-0003-2847-3355UNSPECIFIED
Spasojevic, BrankicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vidal, EnricoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vondrak, KarelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yilmaz, AlevUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zaloszyc, ArianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischbach, MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer, FranzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmitt, Claus PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-176575
DOI: 10.1186/s12882-018-0998-y
Journal or Publication Title: BMC Nephrol.
Volume: 19
Date: 2018
Publisher: BMC
Place of Publication: LONDON
ISSN: 1471-2369
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INTIMA-MEDIA THICKNESS; CHRONIC KIDNEY-DISEASE; ALL-CAUSE MORTALITY; ONLINE-HEMODIAFILTRATION; VASCULAR CALCIFICATION; PEDIATRIC-PATIENTS; DIALYSIS PATIENTS; REFERENCE VALUES; BLOOD-PRESSURE; VOLUMEMultiple languages
Urology & NephrologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/17657

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