Universität zu Köln

Rosjat, Nils, Liu, Liqing, Wang, Bin A., Popovych, Svitlana, Toth, Tibor, Viswanathan, Shivakumar ORCID: 0000-0002-7513-3778, Grefkes, Christian ORCID: 0000-0002-1656-720X, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Daun, Silvia ORCID: 0000-0001-7342-1015 (2018). Aging-associated changes of movement-related functional connectivity in the human brain. Neuropsychologia, 117. S. 520 - 530. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-3514

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Abstract

Motor performance declines with normal aging. Previous neuroimaging work revealed aging-related general increases in neural activity, especially in the prefrontal and pre-motor areas, associated with a loss of hemispheric lateralization. However, the functional mechanisms underlying these changes and their relation to aging associated motor decline to date remain elusive. To further elucidate the neural processes underlying aging-related motor decline, we recorded EEG from younger and older subjects while they performed a finger-tapping task. As a measure of synchronization between motor areas, we computed the inter-regional phase-locking value which reflects functional connectivity between distinct neural populations. Behavioral data revealed increased movement times in older subjects. EEG data showed that phase locking in the delta-theta frequencies is a general, age-independent phenomenon underlying the execution of simple finger movements. In stark contrast, the extent of synchronization between motor areas significantly differed dependent upon age of subjects: multiple additional intra- and inter-hemispheric connections were observed in older subjects. Our data shed light upon the results of previous neuroimaging studies showing aging-related increases in neural activation. In particular, data suggest that the observed aging-dependent substantial intra- and interhemispheric reorganization of connectivity between the corresponding motor areas underlies the previously reported loss of lateralization in older subjects. The changes observed are likely to represent compensatory mechanisms aiming at preserved task performance in older subjects.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rosjat, Nils UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Liqing UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Bin A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Popovych, Svitlana UNSPECIFIED UNSPECIFIED UNSPECIFIED Toth, Tibor UNSPECIFIED UNSPECIFIED UNSPECIFIED Viswanathan, Shivakumar UNSPECIFIED orcid.org/0000-0002-7513-3778 UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Daun, Silvia UNSPECIFIED orcid.org/0000-0001-7342-1015 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-177480
DOI:	10.1016/j.neuropsychologia.2018.07.006
Journal or Publication Title:	Neuropsychologia
Volume:	117
Page Range:	S. 520 - 530
Date:	2018
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-3514
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TASK-DEPENDENT MODULATION; MONKEY MOTOR CORTEX; CORTICAL CONNECTIVITY; PHASE-LOCKING; SYNCHRONY; COMMUNICATION; NETWORKS; MEMORY; INVENTORY; COHERENCE Multiple languages Behavioral Sciences; Neurosciences; Psychology, Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17748