Universität zu Köln

Tiku, Varnesh and Antebi, Adam (2018). Nucleolar Function in Lifespan Regulation. Trends Cell Biol., 28 (8). S. 662 - 673. LONDON: ELSEVIER SCIENCE LONDON. ISSN 1879-3088

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Abstract

The nucleolus is a prominent membraneless organelle residing within the nucleus. The nucleolus has been regarded as a housekeeping structure mainly known for its role in ribosomal RNA (rRNA) production and ribosome assembly. However, accumulating evidence has revealed its functions in numerous cellular processes that control organismal physiology, thereby taking the nucleolus much beyond its conventional role in ribosome biogenesis. Perturbations in nucleolar functions have been associated with severe diseases such as cancer and progeria. Recent studies have also uncovered the role of the nucleolus in development and aging. In this review we discuss major nucleolar functions that impact organismal aging.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tiku, Varnesh UNSPECIFIED UNSPECIFIED UNSPECIFIED Antebi, Adam UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-178992
DOI:	10.1016/j.tcb.2018.03.007
Journal or Publication Title:	Trends Cell Biol.
Volume:	28
Number:	8
Page Range:	S. 662 - 673
Date:	2018
Publisher:	ELSEVIER SCIENCE LONDON
Place of Publication:	LONDON
ISSN:	1879-3088
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RNA-POLYMERASE-I; TERMINAL ACTIVATION DOMAIN; EMBRYONIC STEM-CELLS; CAENORHABDITIS-ELEGANS; RIBOSOMAL-RNA; TOR PATHWAY; C-ELEGANS; SIGNALING PATHWAYS; REDUCED EXPRESSION; SOMATIC-CELLS Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17899