Universität zu Köln

Meyer, Carolin, Bendella, Habib, Rink, Svenja, Gensch, Robin, Seitz, Robert, Stein, Gregor, Manthou, Marilena, Papamitsou, Theodora, Nakamura, Makoto, Bouillon, Bertil, Galea, Mary ORCID: 0000-0003-0045-7978, Batchelor, Peter, Dunlop, Sarah ORCID: 0000-0002-1306-3962 and Angelov, Doychin (2018). The effect of myelotomy following low thoracic spinal cord compression injury in rats. Exp. Neurol., 306. S. 10 - 22. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1090-2430

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Abstract

Myelotomy is a surgical procedure allowing removal of extravasated blood and necrotic tissue that is thought to attenuate secondary injury as well as promote recovery in experimental spinal cord injury (SCI) models and humans. Here we examined in rat whether myelotomy at 48 h after low-thoracic compressive SCI provided any benefit over a 12 week period. Compared to animals receiving SCI alone, myelotomy worsened BBB scores (p < 0.05) and also did not improve plantar stepping, ladder climbing, urinary bladder voiding or sensory function (thermal latency) during the 12-week period. Quantitative analyses of tissue sections at 12 weeks showed that myelotomy also did not reduce lesion volume nor alter immunohistochemical markers of axons in spared white matter bridges, microglia, astrocytes or serotinergic fibres. However, myelotomy reduced synaptophysin expression, a marker of synaptic plasticity. We conclude that further studies are required to evaluate myelotomy after SCI. (142 words).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Meyer, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Bendella, Habib UNSPECIFIED UNSPECIFIED UNSPECIFIED Rink, Svenja UNSPECIFIED UNSPECIFIED UNSPECIFIED Gensch, Robin UNSPECIFIED UNSPECIFIED UNSPECIFIED Seitz, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Stein, Gregor UNSPECIFIED UNSPECIFIED UNSPECIFIED Manthou, Marilena UNSPECIFIED UNSPECIFIED UNSPECIFIED Papamitsou, Theodora UNSPECIFIED UNSPECIFIED UNSPECIFIED Nakamura, Makoto UNSPECIFIED UNSPECIFIED UNSPECIFIED Bouillon, Bertil UNSPECIFIED UNSPECIFIED UNSPECIFIED Galea, Mary UNSPECIFIED orcid.org/0000-0003-0045-7978 UNSPECIFIED Batchelor, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Dunlop, Sarah UNSPECIFIED orcid.org/0000-0002-1306-3962 UNSPECIFIED Angelov, Doychin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-179273
DOI:	10.1016/j.expneurol.2018.04.011
Journal or Publication Title:	Exp. Neurol.
Volume:	306
Page Range:	S. 10 - 22
Date:	2018
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1090-2430
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FUNCTIONAL RECOVERY; EPIDEMIOLOGY; CONTUSION; BARRIER Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17927