Universität zu Köln

Kasper, Maren, Walscheid, Karoline, Laffer, Bjoern, Bauer, Dirk, Busch, Martin, Wildschuetz, Lena, Wang, Bo, Loser, Karin, Vogl, Thomas, Grajewski, Rafael S., Langmann, Thomas and Heiligenhaus, Arnd (2018). The Phenotype of Monocytes in anterior Uveitis Depends on the hla-B27 status. Front. Immunol., 9. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-3224

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Abstract

HLA-B27 is the allele most frequently associated with human anterior uveitis. The majority of HLA-B27-positive [acute anterior uveitis (AAU)] patients develop clinically distinct symptoms with acute symptomatic onset of flare and a recurrent disease course characterized by a massive cellular ocular infiltrate during uveitis relapse. By contrast, uveitis in HLA-B27-negative [idiopathic anterior uveitis (IAU)] patients tends to develop a clinically less fulminant, more chronic, and typically asymptomatic disease course. To analyze systemic immune responses in the different uveitis entities, we analyzed peripheral blood cells by flow cytometry. In addition, as a pro-inflammatory biomarker serum, S100A8/A9 levels were quantified by ELISA from patients with AAU (n = 27) and IAU (n = 21), and in healthy controls (n = 30). Data were obtained either during active uveitis flare or after 3 months of inactivity. IAU patients showed a transiently increased frequency of CD56-and CD163-positive monocytes and of both granulocytic myeloid-derived suppressor cells and Th17 cells during active uveitis. By contrast, AAU patients showed an elevated frequency of monocytes, activated T cells, and elevated S100A8/ A9 serum levels during clinically quiescent disease. The differentially regulated response of both innate and adaptive immune cells in the blood may be related to the clinically distinct characteristics of the two different uveitis entities.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kasper, Maren UNSPECIFIED UNSPECIFIED UNSPECIFIED Walscheid, Karoline UNSPECIFIED UNSPECIFIED UNSPECIFIED Laffer, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Busch, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Wildschuetz, Lena UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Bo UNSPECIFIED UNSPECIFIED UNSPECIFIED Loser, Karin UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogl, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Grajewski, Rafael S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langmann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Heiligenhaus, Arnd UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-179378
DOI:	10.3389/fimmu.2018.01773
Journal or Publication Title:	Front. Immunol.
Volume:	9
Date:	2018
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-3224
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUPPRESSOR-CELLS; RHEUMATOID-ARTHRITIS; CD16(+) MONOCYTES; SUBSET; INFLAMMATION; EXPANSION; DIFFERENTIATION; NOMENCLATURE; ACTIVATION; S100A8/A9 Multiple languages Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17937