Universität zu Köln

Oberste, Max ORCID: 0000-0002-1224-5385, Grossheinrich, Nicola, Wunram, Heidrun-Lioba, Graf, Johannes Levin, Ziemendorff, Alischa, Meinhardt, Axel, Fricke, Oliver, Mahabir, Esther and Bender, Stephan (2018). Effects of a 6-week, whole-body vibration strength-training on depression symptoms, endocrinological and neurobiological parameters in adolescent inpatients experiencing a major depressive episode (the Balancing Vibrations Study): study protocol for a randomized placebo-controlled trial. Trials, 19. LONDON: BMC. ISSN 1745-6215

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Abstract

Background: Moderate to vigorous endurance and strength-training exercise was suggested as a treatment option for major depression. However, there is little evidence to support this suggestion in adolescent patients. The present study investigates the effects of a whole-body vibration strength-training intervention on symptoms in medication-naive adolescent inpatients experiencing a major depressive episode. Potential underlying endocrinological and neurobiological mechanisms are explored. Methods/design: A double-blinded randomized controlled trial is conducted at the University Hospital of Cologne in Germany, comparing a 6-week, whole-body vibration strength-training with a 6-week placebo-intervention, as add-on therapy to inpatient treatment as usual. Forty-one subjects (13-18 years of age) will be included in each of the two groups. The study is powered to detect (alpha = .05, beta= .2) a medium effect size difference between the two groups (d = .5) in terms of patients' change in the Children's Depression Rating Scale raw-score, from baseline until the end of the intervention. As secondary endpoints, the effects of exercise treatment on patients' cortisol awakening response as well as on brain-derived neurotrophic factor, insulin-like growth factor 1 and inflammatory markers (tumor necrosis factor-alpha, interleukin-6 and C-reactive protein) serum levels will be assessed. Discussion: This study will provide evidence on the effectiveness of whole-body vibration strength-training as an add-on therapy in adolescent inpatients experiencing a major depressive episode. After completion of data collection, the present study will be the largest randomized controlled trial so far to investigate the effectiveness of an exercise intervention in inpatient adolescents suffering from a major depressive episode. Moreover, the present study may help to determine the underlying mechanisms of potential anti-depressant effects of exercise in depressed adolescent inpatients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Oberste, Max UNSPECIFIED orcid.org/0000-0002-1224-5385 UNSPECIFIED Grossheinrich, Nicola UNSPECIFIED UNSPECIFIED UNSPECIFIED Wunram, Heidrun-Lioba UNSPECIFIED UNSPECIFIED UNSPECIFIED Graf, Johannes Levin UNSPECIFIED UNSPECIFIED UNSPECIFIED Ziemendorff, Alischa UNSPECIFIED UNSPECIFIED UNSPECIFIED Meinhardt, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Fricke, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Mahabir, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Bender, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-180007
DOI:	10.1186/s13063-018-2747-8
Journal or Publication Title:	Trials
Volume:	19
Date:	2018
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1745-6215
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PSYCHIATRIC-DISORDERS; CHILDREN; EXERCISE; FLUOXETINE; ANXIETY; HEALTH; STRESS; SERUM; TADS Multiple languages Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18000