Universität zu Köln

Arbizu, Javier ORCID: 0000-0002-8370-5510, Festari, Cristina ORCID: 0000-0003-3597-5097, Altomare, Daniele ORCID: 0000-0003-1905-8993, Walker, Zuzana ORCID: 0000-0001-7346-8200, Bouwman, Femke, Rivolta, Jasmine, Orini, Stefania, Barthel, Henryk, Agosta, Federica ORCID: 0000-0003-3121-4979, Drzezga, Alexander, Nestor, Peter ORCID: 0000-0002-5860-5921, Boccardi, Marina ORCID: 0000-0001-6744-8246, Frisoni, Giovanni Battista and Nobili, Flavio ORCID: 0000-0001-9811-0897 (2018). Clinical utility of FDG-PET for the clinical diagnosis in MCI. Eur. J. Nucl. Med. Mol. Imaging, 45 (9). S. 1497 - 1509. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

We aim to report the quality of accuracy studies investigating the utility of [F-18]fluorodeoxyglucose (FDG)-PET in supporting the diagnosis of prodromal Alzheimer's Disease (AD), frontotemporal lobar degeneration (FTLD) and prodromal dementia with Lewy bodies (DLB) in mild cognitive impairment (MCI) subjects, and the corresponding recommendations made by a panel of experts. Seven panellist, four from the European Association of Nuclear Medicine, and three from the European Academy of Neurology, produced recommendations taking into consideration the incremental value of FDG-PET, as added on clinical-neuropsychological examination, to ascertain the aetiology of MCI (AD, FTLD or DLB). A literature search using harmonized population, intervention, comparison, and outcome (PICO) strings was performed, and an evidence assessment consistent with the European Federation of Neurological Societies guidance was provided. The consensual recommendation was achieved based on Delphi rounds. Fifty-four papers reported the comparison of interest. The selected papers allowed the identification of FDG patterns that characterized MCI due to AD, FTLD and DLB. While clinical outcome studies supporting the diagnosis of MCI due to AD showed varying accuracies (ranging from 58 to 100%) and varying areas under the receiver-operator characteristic curves (0.66 to 0.97), no respective data were identified for MCI due to FTLD or for MCI due to DLB. However, the high negative predictive value of FDG-PET and the existence of different disease-specific patterns of hypometabolism support the consensus recommendations for the clinical use of this imaging technique in MCI subjects. FDG-PET has clinical utility on a fair level of evidence in detecting MCI due to AD. Although promising also in detecting MCI due to FTLD and MCI due to DLB, more research is needed to ultimately judge the clinical utility of FDG-PET in these entities.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Arbizu, Javier UNSPECIFIED orcid.org/0000-0002-8370-5510 UNSPECIFIED Festari, Cristina UNSPECIFIED orcid.org/0000-0003-3597-5097 UNSPECIFIED Altomare, Daniele UNSPECIFIED orcid.org/0000-0003-1905-8993 UNSPECIFIED Walker, Zuzana UNSPECIFIED orcid.org/0000-0001-7346-8200 UNSPECIFIED Bouwman, Femke UNSPECIFIED UNSPECIFIED UNSPECIFIED Rivolta, Jasmine UNSPECIFIED UNSPECIFIED UNSPECIFIED Orini, Stefania UNSPECIFIED UNSPECIFIED UNSPECIFIED Barthel, Henryk UNSPECIFIED UNSPECIFIED UNSPECIFIED Agosta, Federica UNSPECIFIED orcid.org/0000-0003-3121-4979 UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Nestor, Peter UNSPECIFIED orcid.org/0000-0002-5860-5921 UNSPECIFIED Boccardi, Marina UNSPECIFIED orcid.org/0000-0001-6744-8246 UNSPECIFIED Frisoni, Giovanni Battista UNSPECIFIED UNSPECIFIED UNSPECIFIED Nobili, Flavio UNSPECIFIED orcid.org/0000-0001-9811-0897 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-180326
DOI:	10.1007/s00259-018-4039-7
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	45
Number:	9
Page Range:	S. 1497 - 1509
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; POSITRON-EMISSION-TOMOGRAPHY; ALZHEIMERS ASSOCIATION WORKGROUPS; F-18-FDG PET; FOLLOW-UP; BEHAVIORAL VARIANT; AMNESTIC MCI; PROBABILISTIC PREDICTION; NATIONAL INSTITUTE; PRODROMAL DEMENTIA Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18032