Universität zu Köln

Nestor, Peter J., Altomare, Daniele ORCID: 0000-0003-1905-8993, Festari, Cristina ORCID: 0000-0003-3597-5097, Drzezga, Alexander, Rivolta, Jasmine, Walker, Zuzana ORCID: 0000-0001-7346-8200, Bouwman, Femke, Orini, Stefania, Law, Ian, Agosta, Federica ORCID: 0000-0003-3121-4979, Arbizu, Javier ORCID: 0000-0002-8370-5510, Boccardi, Marina ORCID: 0000-0001-6744-8246, Nobili, Flavio ORCID: 0000-0001-9811-0897 and Frisoni, Giovanni Battista (2018). Clinical utility of FDG-PET for the differential diagnosis among the main forms of dementia. Eur. J. Nucl. Med. Mol. Imaging, 45 (9). S. 1509 - 1526. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

To assess the clinical utility of FDG-PET as a diagnostic aid for differentiating Alzheimer's disease (AD; both typical and atypical forms), dementia with Lewy bodies (DLB), frontotemporal lobar degeneration (FTLD), vascular dementia (VaD) and non-degenerative pseudodementia. A comprehensive literature search was conducted using the PICO model to extract evidence from relevant studies. An expert panel then voted on six different diagnostic scenarios using the Delphi method. The level of empirical study evidence for the use of FDG-PET was considered good for the discrimination of DLB and AD; fair for discriminating FTLD from AD; poor for atypical AD; and lacking for discriminating DLB from FTLD, AD from VaD, and for pseudodementia. Delphi voting led to consensus in all scenarios within two iterations. Panellists supported the use of FDG-PET for all PICOs-including those where study evidence was poor or lacking-based on its negative predictive value and on the assistance it provides when typical patterns of hypometabolism for a given diagnosis are observed. Although there is an overall lack of evidence on which to base strong recommendations, it was generally concluded that FDG-PET has a diagnostic role in all scenarios. Prospective studies targeting diagnostically uncertain patients for assessing the added value of FDG-PET would be highly desirable.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nestor, Peter J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Altomare, Daniele UNSPECIFIED orcid.org/0000-0003-1905-8993 UNSPECIFIED Festari, Cristina UNSPECIFIED orcid.org/0000-0003-3597-5097 UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Rivolta, Jasmine UNSPECIFIED UNSPECIFIED UNSPECIFIED Walker, Zuzana UNSPECIFIED orcid.org/0000-0001-7346-8200 UNSPECIFIED Bouwman, Femke UNSPECIFIED UNSPECIFIED UNSPECIFIED Orini, Stefania UNSPECIFIED UNSPECIFIED UNSPECIFIED Law, Ian UNSPECIFIED UNSPECIFIED UNSPECIFIED Agosta, Federica UNSPECIFIED orcid.org/0000-0003-3121-4979 UNSPECIFIED Arbizu, Javier UNSPECIFIED orcid.org/0000-0002-8370-5510 UNSPECIFIED Boccardi, Marina UNSPECIFIED orcid.org/0000-0001-6744-8246 UNSPECIFIED Nobili, Flavio UNSPECIFIED orcid.org/0000-0001-9811-0897 UNSPECIFIED Frisoni, Giovanni Battista UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-180337
DOI:	10.1007/s00259-018-4035-y
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	45
Number:	9
Page Range:	S. 1509 - 1526
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; MILD COGNITIVE IMPAIRMENT; CEREBRAL GLUCOSE-METABOLISM; ALZHEIMERS ASSOCIATION WORKGROUPS; POSTERIOR CORTICAL ATROPHY; LEWY BODIES; FRONTOTEMPORAL DEMENTIA; BEHAVIORAL VARIANT; F-18-FDG PET; VASCULAR DEMENTIA Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18033