Universität zu Köln

Bouwman, Femke, Orini, Stefania, Gandolfo, Federica, Altomare, Daniele ORCID: 0000-0003-1905-8993, Festari, Cristina ORCID: 0000-0003-3597-5097, Agosta, Federica ORCID: 0000-0003-3121-4979, Arbizu, Javier ORCID: 0000-0002-8370-5510, Drzezga, Alexander, Nestor, Peter ORCID: 0000-0002-5860-5921, Nobili, Flavio ORCID: 0000-0001-9811-0897, Walker, Zuzana ORCID: 0000-0001-7346-8200, Morbelli, Silvia ORCID: 0000-0002-7833-6095 and Boccardi, Marina ORCID: 0000-0001-6744-8246 (2018). Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasia. Eur. J. Nucl. Med. Mol. Imaging, 45 (9). S. 1526 - 1534. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

A joint effort of the European Association of Nuclear Medicine (EANM) and the European Academy of Neurology (EAN) aims at clinical guidance for the use of FDG-PET in neurodegenerative diseases. This paper addresses the diagnostic utility of FDG-PET over clinical/neuropsychological assessment in the differentiation of the three forms of primary progressive aphasia (PPA). Seven panelists were appointed by the EANM and EAN and a literature search was performed by using harmonized PICO (Population, Intervention, Comparison, Outcome) question keywords. The studies were screened for eligibility, and data extracted to assess their methodological quality. Critical outcomes were accuracy indices in differentiating different PPA clinical forms. Subsequently Delphi rounds were held with the extracted data and quality assessment to reach a consensus based on both literature and expert opinion. Critical outcomes for this PICO were available in four of the examined papers. The level of formal evidence supporting clinical utility of FDG-PET in differentiating among PPA variants was considered as poor. However, the consensual recommendation was defined on Delphi round I, with six out of seven panelists supporting clinical use. Quantitative evidence demonstrating utility or lack thereof is still missing. Panelists decided consistently to provide interim support for clinical use based on the fact that a typical atrophy or metabolic pattern is needed for PPA according to the diagnostic criteria, and the synaptic failure detected by FDG-PET is an earlier phenomenon than atrophy. Also, a normal FDG-PET points to a non-neurodegenerative cause.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bouwman, Femke UNSPECIFIED UNSPECIFIED UNSPECIFIED Orini, Stefania UNSPECIFIED UNSPECIFIED UNSPECIFIED Gandolfo, Federica UNSPECIFIED UNSPECIFIED UNSPECIFIED Altomare, Daniele UNSPECIFIED orcid.org/0000-0003-1905-8993 UNSPECIFIED Festari, Cristina UNSPECIFIED orcid.org/0000-0003-3597-5097 UNSPECIFIED Agosta, Federica UNSPECIFIED orcid.org/0000-0003-3121-4979 UNSPECIFIED Arbizu, Javier UNSPECIFIED orcid.org/0000-0002-8370-5510 UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Nestor, Peter UNSPECIFIED orcid.org/0000-0002-5860-5921 UNSPECIFIED Nobili, Flavio UNSPECIFIED orcid.org/0000-0001-9811-0897 UNSPECIFIED Walker, Zuzana UNSPECIFIED orcid.org/0000-0001-7346-8200 UNSPECIFIED Morbelli, Silvia UNSPECIFIED orcid.org/0000-0002-7833-6095 UNSPECIFIED Boccardi, Marina UNSPECIFIED orcid.org/0000-0001-6744-8246 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-180347
DOI:	10.1007/s00259-018-4034-z
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	45
Number:	9
Page Range:	S. 1526 - 1534
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALZHEIMERS-DISEASE; F-18-FDG PET; RECOMMENDATIONS; CRITERIA Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18034