Universität zu Köln

Nobili, Flavio ORCID: 0000-0001-9811-0897, Festari, Cristina ORCID: 0000-0003-3597-5097, Altomare, Daniele ORCID: 0000-0003-1905-8993, Agosta, Federica ORCID: 0000-0003-3121-4979, Orini, Stefania, Van Laere, Koen, Arbizu, Javier ORCID: 0000-0002-8370-5510, Bouwman, Femke, Drzezga, Alexander, Nestor, Peter ORCID: 0000-0002-5860-5921, Walker, Zuzana ORCID: 0000-0001-7346-8200 and Boccardi, Marina ORCID: 0000-0001-6744-8246 (2018). Automated assessment of FDG-PET for differential diagnosis in patients with neurodegenerative disorders. Eur. J. Nucl. Med. Mol. Imaging, 45 (9). S. 1557 - 1567. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

To review literature until November 2015 and reach a consensus on whether automatic semi-quantification of brain FDG-PET is useful in the clinical setting for neurodegenerative disorders. A literature search was conducted in Medline, Embase, and Google Scholar. Papers were selected with a lower limit of 30 patients (no limits with autopsy confirmation). Consensus recommendations were developed through a Delphi procedure, based on the expertise of panelists, who were also informed about the availability and quality of evidence, assessed by an independent methodology team. Critical outcomes were available in nine among the 17 papers initially selected. Only three papers performed a direct comparison between visual and automated assessment and quantified the incremental value provided by the latter. Sensitivity between visual and automatic analysis is similar but automatic assessment generally improves specificity and marginally accuracy. Also, automated assessment increases diagnostic confidence. As expected, performance of visual analysis is reported to depend on the expertise of readers. Tools for semi-quantitative evaluation are recommended to assist the nuclear medicine physician in reporting brain FDG-PET pattern in neurodegenerative conditions. However, heterogeneity, complexity, and drawbacks of these tools should be known by users to avoid misinterpretation. Head-to-head comparisons and an effort to harmonize procedures are encouraged.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nobili, Flavio UNSPECIFIED orcid.org/0000-0001-9811-0897 UNSPECIFIED Festari, Cristina UNSPECIFIED orcid.org/0000-0003-3597-5097 UNSPECIFIED Altomare, Daniele UNSPECIFIED orcid.org/0000-0003-1905-8993 UNSPECIFIED Agosta, Federica UNSPECIFIED orcid.org/0000-0003-3121-4979 UNSPECIFIED Orini, Stefania UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Laere, Koen UNSPECIFIED UNSPECIFIED UNSPECIFIED Arbizu, Javier UNSPECIFIED orcid.org/0000-0002-8370-5510 UNSPECIFIED Bouwman, Femke UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Nestor, Peter UNSPECIFIED orcid.org/0000-0002-5860-5921 UNSPECIFIED Walker, Zuzana UNSPECIFIED orcid.org/0000-0001-7346-8200 UNSPECIFIED Boccardi, Marina UNSPECIFIED orcid.org/0000-0001-6744-8246 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-180373
DOI:	10.1007/s00259-018-4030-3
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	45
Number:	9
Page Range:	S. 1557 - 1567
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEREOTAXIC SURFACE PROJECTIONS; MILD COGNITIVE IMPAIRMENT; DISEASE CONSORTIUM EADC; ALZHEIMERS-DISEASE; VISUAL ASSESSMENT; F-18-FDG PET; DEMENTIA; SYSTEM; DISCRIMINATION; NORMALIZATION Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18037