Universität zu Köln

Fischer, Karina, van Lent, Debora Melo, Wolfsgruber, Steffen, Weinhold, Leonie, Kleineidam, Luca, Bickel, Horst, Scherer, Martin, Eisele, Marion, van den Bussche, Hendrik, Wiese, Birgitt, Koenig, Hans-Helmut, Weyerer, Siegfried, Pentzek, Michael, Roehr, Susanne ORCID: 0000-0001-9385-0669, Maier, Wolfgang, Jessen, Frank, Schmid, Matthias ORCID: 0000-0002-0788-0317, Riedel-Heller, Steffi G. and Wagner, Michael ORCID: 0000-0003-2589-6440 (2018). Prospective Associations between Single Foods, Alzheimer's Dementia and Memory Decline in the Elderly. Nutrients, 10 (7). BASEL: MDPI. ISSN 2072-6643

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Abstract

Background: Evidence whether single cognitive health foods could prevent cognitive decline is limited. We investigated whether dietary intake of red wine, white wine, coffee, green tea, olive oil, fresh fish, fruits and vegetables, red meat and sausages, assessed by a single-food-questionnaire, would be associated with either incident Alzheimer's dementia (AD) or verbal memory decline. Methods: Participants aged 75+ of the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) cohort were regularly followed over 10 years (n = 2622; n = 418 incident AD cases). Multivariable-adjusted joint modeling of repeated-measures and survival analysis was used, taking gender and Apolipoprotein E4 (APOE epsilon 4) genotype into account as possible effect modifiers. Results: Only higher red wine intake was associated with a lower incidence of AD (HR = 0.92; P = 0.045). Interestingly, this was true only for men (HR = 0.82; P < 0.001), while in women higher red wine intake was associated with a higher incidence of AD (HR = 1.15; P = 0.044), and higher white wine intake with a more pronounced memory decline over time (HR = -0.13; P = 0.052). Conclusion: We found no evidence for these single foods to be protective against cognitive decline, with the exception of red wine, which reduced the risk for AD only in men. Women could be more susceptible to detrimental effects of alcohol.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fischer, Karina UNSPECIFIED UNSPECIFIED UNSPECIFIED van Lent, Debora Melo UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolfsgruber, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Weinhold, Leonie UNSPECIFIED UNSPECIFIED UNSPECIFIED Kleineidam, Luca UNSPECIFIED UNSPECIFIED UNSPECIFIED Bickel, Horst UNSPECIFIED UNSPECIFIED UNSPECIFIED Scherer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Eisele, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED van den Bussche, Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiese, Birgitt UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Hans-Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Weyerer, Siegfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Pentzek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Roehr, Susanne UNSPECIFIED orcid.org/0000-0001-9385-0669 UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmid, Matthias UNSPECIFIED orcid.org/0000-0002-0788-0317 UNSPECIFIED Riedel-Heller, Steffi G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-180768
DOI:	10.3390/nu10070852
Journal or Publication Title:	Nutrients
Volume:	10
Number:	7
Date:	2018
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6643
Language:	English
Faculty:	Faculty of Management, Economy and Social Sciences
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-CHAIN OMEGA-3-FATTY-ACIDS; POLYUNSATURATED FATTY-ACIDS; DOSE-RESPONSE METAANALYSIS; TO-EVENT DATA; AGED 75 YEARS; COGNITIVE DECLINE; APOLIPOPROTEIN-E; ALCOHOL-CONSUMPTION; COFFEE CONSUMPTION; DIETARY PATTERNS Multiple languages Nutrition & Dietetics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18076