Bader, Peter, Kuci, Zyrafete, Bakhtiar, Shahrzad, Basu, Oliver, Bug, Gesine, Dennis, Michael, Greil, Johann, Barta, Aniko, Kallay, Krisztian M., Lang, Peter, Lucchini, Giovanna, Pol, Raj, Schulz, Ansgar, Sykora, Karl-Walter, von Luettichau, Irene, Herter-Sprie, Grit, Uddin, Mohammad Ashab, Jenkin, Phil, Alsultan, Abdulrahman, Buechner, Jochen, Stein, Jerry, Kelemen, Agnes, Jarisch, Andrea, Soerensen, Jan, Salzmann-Manrique, Emilia, Hutter, Martin, Schaefer, Richard, Seifried, Erhard, Klingebiel, Thomas, Bonig, Halvard and Kuci, Selim ORCID: 0000-0002-0105-1083 (2018). Effective treatment of steroid and therapy-refractory acute graft-versus-host disease with a novel mesenchymal stromal cell product (MSC-FFM). Bone Marrow Transplant., 53 (7). S. 852 - 863. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5365

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Abstract

The inability to generate mesenchymal stromal cells (MSCs) of consistent potency likely is responsible for inconsistent clinical outcomes of patients with aGvHD receiving MSC products. We developed a novel MSC manufacturing protocol characterized by high in vitro potency and near-identity of individual doses, referred to as MSC-Frankfurt am Main (MSC-FFM). Herein, we report outcomes of the 69 patients who have received MSC-FFM. These were 51 children and 18 adults with refractory aGvHD grade II (4%), III (36%) or IV (59%). Patients were refractory either to frontline therapy (steroids) (29%) or to steroids and 1-5 additional lines of immunosuppressants (71%) were given infusions in four weekly intervals. The day 28 overall response rate was 83%; at the last follow-up, 61% and 25% of patients were in complete or partial remission. The median follow-up was 8.1 months. Six-month estimate for cumulative incidence of non-relapse mortality was 27% (range, 16-38); leukemia relapse mortality was 2% (range, 0-5). This was associated with a superior six-month overall survival (OS) probability rate of 71% (range, 61-83), compared to the outcome of patients not treated with MSC-FFM. This novel product was effective in children and adults, suggesting that MSC-FFM represents a promising therapy for steroid refractory aGvHD.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bader, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuci, ZyrafeteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bakhtiar, ShahrzadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Basu, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bug, GesineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dennis, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Greil, JohannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barta, AnikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kallay, Krisztian M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lang, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lucchini, GiovannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pol, RajUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulz, AnsgarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sykora, Karl-WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Luettichau, IreneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herter-Sprie, GritUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Uddin, Mohammad AshabUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jenkin, PhilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alsultan, AbdulrahmanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buechner, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stein, JerryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kelemen, AgnesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jarisch, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soerensen, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salzmann-Manrique, EmiliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hutter, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seifried, ErhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klingebiel, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonig, HalvardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuci, SelimUNSPECIFIEDorcid.org/0000-0002-0105-1083UNSPECIFIED
URN: urn:nbn:de:hbz:38-181584
DOI: 10.1038/s41409-018-0102-z
Journal or Publication Title: Bone Marrow Transplant.
Volume: 53
Number: 7
Page Range: S. 852 - 863
Date: 2018
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1476-5365
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PEDIATRIC-PATIENTS; STEM-CELLS; ACUTE GVHD; MULTICENTER SURVEY; TRANSPLANTATION; RESISTANT; MARROW; ADULT; RESPONSES; SURVIVALMultiple languages
Biophysics; Oncology; Hematology; Immunology; TransplantationMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18158

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