Universität zu Köln

Seyhan, Harun, Stromps, Jan-Phillip, Demir, Erhan, Fuchs, Paul C. and Kopp, Juergen (2018). Vitamin D deficiency may stimulate fibroblasts in Dupuytren's disease via mitochondrial increased reactive oxygen species through upregulating transforming growth factor-beta 1. Med. Hypotheses, 116. S. 40 - 42. EDINBURGH: CHURCHILL LIVINGSTONE. ISSN 1532-2777

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Abstract

Dupuytren's disease, a benign fibroproliferative disorder of the palmar fascia, represents an ideal model to study tissue fibrosis. Transforming growth factor-beta 1 (TGF-beta 1) and its downstream Smad signaling system is well established as a keyplayer during fibrogenesis. Vitamin D has been extensively studied as an anti-fibrotic agent in malignant chronic diseases. A number of studies have shown that myofibroblasts are main target cells of 1,25(OH)(2)D-3 inhibitory action. The myofibroblast in the palmar aponeurosis of patients in different stages of Dupuytren's disease was found by electron microscopy to contain a large number of mitochondria. Mitochondria play a critical role in cell metabolism being the major source of reactive oxygen species (ROS) in cells. TGF-beta 1 has been shown to increase mitochondrial ROS production in different cell types, which mediate fibrosis related gene expression and myofibroblast differentiation. TGF-beta 1 increases mitochondrial ROS production in patients with Dupuytren's contracture potentially in consequence of Vitamin D deficiency, leading to myofibroblast differentiation. Thus, targeting this basic pathomechanism seems suitable to establish new treatment strategies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Seyhan, Harun UNSPECIFIED UNSPECIFIED UNSPECIFIED Stromps, Jan-Phillip UNSPECIFIED UNSPECIFIED UNSPECIFIED Demir, Erhan UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuchs, Paul C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kopp, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-181745
DOI:	10.1016/j.mehy.2018.04.016
Journal or Publication Title:	Med. Hypotheses
Volume:	116
Page Range:	S. 40 - 42
Date:	2018
Publisher:	CHURCHILL LIVINGSTONE
Place of Publication:	EDINBURGH
ISSN:	1532-2777
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GROWTH-FACTOR-BETA; SMOOTH MUSCLE ACTIN; TGF-BETA; GRANULATION-TISSUE; CONTRACTURE; MYOFIBROBLASTS; EXPRESSION; COLLAGEN; ALCOHOL; PATHOGENESIS Multiple languages Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18174