Universität zu Köln

Hoehfeld, Joerg and Hoppe, Thorsten ORCID: 0000-0002-4734-9352 (2018). Ub and Down: Ubiquitin Exercise for the Elderly. Trends Cell Biol., 28 (7). S. 512 - 523. LONDON: ELSEVIER SCIENCE LONDON. ISSN 1879-3088

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Abstract

Conjugation of ubiquitin onto proteins generates a degradation signal or exerts degradation-independent regulatory functions. Ubiquitylation is governed by the antagonistic action of ubiquitin ligases and deubiquitylating enzymes (DUBs). Several recent publications illustrate a balanced interplay of ligases and DUBs at signaling hubs that are central to longevity and protein homeostasis (proteostasis). In addition, stress-induced alterations of ubiquitin conjugation are emerging as key events that drive aging and contribute to the pathology of age-related diseases. This physiological role of dynamic ubiquitylation further extends its well-known function in protein regulation and quality control at the cellular level. Recent work thus significantly advances our understanding of the aging process both at the molecular and organismal level.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoehfeld, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoppe, Thorsten UNSPECIFIED orcid.org/0000-0002-4734-9352 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-182078
DOI:	10.1016/j.tcb.2018.03.002
Journal or Publication Title:	Trends Cell Biol.
Volume:	28
Number:	7
Page Range:	S. 512 - 523
Date:	2018
Publisher:	ELSEVIER SCIENCE LONDON
Place of Publication:	LONDON
ISSN:	1879-3088
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALPHA-SYNUCLEIN TOXICITY; MACHADO-JOSEPH-DISEASE; LIFE-SPAN; DEUBIQUITINASE USP30; QUALITY-CONTROL; LIGASE CHIP; AUTOPHAGY; PROTEOSTASIS; LONGEVITY; PROTEINS Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18207