Universität zu Köln

Lehmann, Sabrina, Schulze, Bastian ORCID: 0000-0003-4641-8659, Thomas, Andreas ORCID: 0000-0003-1199-0743, Kamphausen, Thomas, Thevis, Mario, Rothschild, Markus A. and Mercer-Chalmers-Bender, Katja ORCID: 0000-0002-3843-9065 (2018). Organ distribution of 4-MEC, MDPV, methoxetamine and alpha-PVP: comparison of QuEChERS and SPE. Forensic Toxicol., 36 (2). S. 320 - 334. NEW YORK: SPRINGER. ISSN 1860-8973

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Abstract

Purpose An organ distribution investigation was carried out on two deceased (A and B) who consumed 4-methylethcathinone (4-MEC), methylenedioxypyrovalerone (MDPV), methoxetamine (MXE) and alpha-pyrrolidinopentiophenone (alpha-PVP). Methods The detection of the aforementioned drugs in the specimens was performed on a liquid chromatography-tandem mass spectrometry system. Two different extraction methods were compared with each other-a quick, easy, cheap, effective, rugged and safe (QuEChERS) approach and an automated Instrument Top Sample Preparation-solid phase extraction (ITSP-SPE). Standard addition method was used to quantify the drugs. Results 4-MEC, MDPV and MXE were detected in all collected tissues and body fluids of the two deceased. alpha-PVP was also detectable in deceased A. Deceased A showed femoral blood concentrations of 97 mu g/L 4-MEC, 396 mu g/L MDPV, 295 mu g/L MXE and 4 mu g/L alpha-PVP measured after extraction by QuEChERS and 118 mu g/L 4-MEC, 342 mu g/L MDPV, 385 mu g/L MXE and 4 mu g/L alpha-PVP measured after ITSP-SPE. Deceased B revealed heart blood concentrations of 8 mu g/L 4-MEC, 3 mu g/L MDPV and 2 mu g/L MXE after extraction by QuEChERS and 8 mu g/L 4-MEC and 1 mu g/L MXE after ITSP-SPE. Conclusions Both preparation techniques were suitable for quantifying NPS in organ tissues and body fluids. With respect to the autopsy findings, the cause of death of deceased A was determined to be an acute intoxication with NPS. No certain cause of death could be ascertained for deceased B.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lehmann, Sabrina UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulze, Bastian UNSPECIFIED orcid.org/0000-0003-4641-8659 UNSPECIFIED Thomas, Andreas UNSPECIFIED orcid.org/0000-0003-1199-0743 UNSPECIFIED Kamphausen, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Rothschild, Markus A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mercer-Chalmers-Bender, Katja UNSPECIFIED orcid.org/0000-0002-3843-9065 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-182109
DOI:	10.1007/s11419-018-0408-y
Journal or Publication Title:	Forensic Toxicol.
Volume:	36
Number:	2
Page Range:	S. 320 - 334
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1860-8973
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SOLID-PHASE EXTRACTION; LIQUID-CHROMATOGRAPHY; FATAL INTOXICATION; BATH SALTS; PSYCHOACTIVE SUBSTANCES; MASS-SPECTROMETRY; RECREATIONAL USE; BLOOD; DRUGS; PYRROLIDINOVALEROPHENONE Multiple languages Toxicology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18210