Universität zu Köln

Thyagaraj, Suraj, Pahlavian, Soroush Heidari, Sass, Lucas R., Loth, Francis, Vatani, Morteza, Choi, Jae-Won, Tubbs, R. Shane, Giese, Daniel ORCID: 0000-0002-3925-4441, Kroger, Jan-Robert, Bunck, Alexander C. and Martin, Bryn A. ORCID: 0000-0003-1234-7880 (2018). An MRI-Compatible Hydrodynamic Simulator of Cerebrospinal Fluid Motion in the Cervical Spine. IEEE Trans. Biomed. Eng., 65 (7). S. 1516 - 1524. PISCATAWAY: IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. ISSN 1558-2531

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Abstract

Goal: Develop and test an MRI-compatible hydrodynamic simulator of cerebrospinal fluid (CSF) motion in the cervical spinal subarachnoid space. Four anatomically realistic subject-specific models were created based on a 22-year-old healthy volunteer and a five-year-old patient diagnosed with Chiari I malformation. Methods: The in vitro models were based on manual segmentation of high-resolution T2-weighted MRI of the cervical spine. Anatomically realistic dorsal and ventral spinal cord nerve rootlets (NR) were added. Models were three dimensional (3-D) printed by stereolithography with 50-mu m layer thickness. A computer controlled pump system was used to replicate the shape of the subject specific in vivo CSF flow measured by phase-contrast MRI. Each model was then scanned by T2-weighted and 4-D phase contrast MRI (4D flow). Results: Cross-sectional area, wetted perimeter, and hydraulic diameter were quantified for each model. The oscillatory CSF velocity field (flow jets near NR, velocity profile shape, and magnitude) had similar characteristics to previously reported studies in the literature measured by in vivo MRI. Conclusion: This study describes the first MRI-compatible hydrodynamic simulator of CSF motion in the cervical spine with anatomically realistic NR. NR were found to impact CSF velocity profiles to a great degree. Significance: CSF hydrodynamics are thought to be altered in craniospinal disorders such as Chiari I malformation. MRI scanning techniques and protocols can be used to quantify CSF flow alterations in disease states. The provided in vitro models can be used to test the reliability of these protocols across MRI scanner manufacturers and machines.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thyagaraj, Suraj UNSPECIFIED UNSPECIFIED UNSPECIFIED Pahlavian, Soroush Heidari UNSPECIFIED UNSPECIFIED UNSPECIFIED Sass, Lucas R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Loth, Francis UNSPECIFIED UNSPECIFIED UNSPECIFIED Vatani, Morteza UNSPECIFIED UNSPECIFIED UNSPECIFIED Choi, Jae-Won UNSPECIFIED UNSPECIFIED UNSPECIFIED Tubbs, R. Shane UNSPECIFIED UNSPECIFIED UNSPECIFIED Giese, Daniel UNSPECIFIED orcid.org/0000-0002-3925-4441 UNSPECIFIED Kroger, Jan-Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Bunck, Alexander C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Martin, Bryn A. UNSPECIFIED orcid.org/0000-0003-1234-7880 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-182114
DOI:	10.1109/TBME.2017.2756995
Journal or Publication Title:	IEEE Trans. Biomed. Eng.
Volume:	65
Number:	7
Page Range:	S. 1516 - 1524
Date:	2018
Publisher:	IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Place of Publication:	PISCATAWAY
ISSN:	1558-2531
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHIARI I MALFORMATION; MAGNETIC-RESONANCE; FORAMEN MAGNUM; CSF FLOW; CRANIOCERVICAL JUNCTION; BLOOD-FLOW; DYNAMICS; SEGMENTATION; RESPIRATION; VELOCITY Multiple languages Engineering, Biomedical Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18211