Universität zu Köln

Heinemann, Melina, Ranft, Andreas ORCID: 0000-0003-4424-7569, Langer, Thorsten, Juergens, Herbert, Kreyer, Justus, Vieth, Volker, Schaefers, Michael, Weckesser, Matthias, Simon, Thorsten, Hassenpflug, Wolf, Corbacioglu, Selim, Bielack, Stefan, Mayer-Steinacker, Regina, Kuehne, Thomas ORCID: 0000-0002-7387-7028, van den Berg, Henk, Gelderblom, Hans, Bauer, Sebastian ORCID: 0000-0001-5949-8120, Stegger, Lars and Dirksen, Uta (2018). Recurrence of Ewing sarcoma: Is detection by imaging follow-up protocol associated with survival advantage? Pediatr. Blood Cancer, 65 (7). HOBOKEN: WILEY. ISSN 1545-5017

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Abstract

BackgroundThe Cooperative Ewing Sarcoma Study and the Late Effects Surveillance System of the Society for Paediatric Oncology and Haematology recommend a structured follow-up imaging protocol (FUIP) for patients with Ewing sarcoma (EwS) with decreasing frequency of imaging over the first 5 years. The present study aims to assess the effectiveness of the FUIP for EwS patients regarding survival after relapse. Patients and methodsA retrospective multicenter analysis on 160 eligible patients with EwS recurrence was performed. Potential survival differences following recurrence diagnosis between patients with protocol-detected and symptomatic relapse were investigated using the Kaplan-Meier method. Additional subgroup analyses were performed on the relapse type. Overall survival (OS) was calculated from diagnosis of relapse to last follow-up or death. ResultsIn the multicenter analysis, recurrence was detected by FUIP in 77 of 160 patients (48%) and due to symptoms in 83 patients (52%). Regarding the entire study population, OS was significantly superior in patients with protocol-detected relapse compared to patients with symptomatic relapse (median, 2.4 vs. 1.2 years; P<0.001). In the subgroup analyses, patients whose lung recurrences were detected by the FUIP experienced longer survival after recurrence than those whose recurrences were detected symptomatically (P=0.023). In the 83 symptomatic patients, pain was the most prevalent symptom of relapse (72%). ConclusionFUIP may benefit survival in EwS relapse, especially in lung recurrence. Pain was the leading symptom of relapse.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heinemann, Melina UNSPECIFIED UNSPECIFIED UNSPECIFIED Ranft, Andreas UNSPECIFIED orcid.org/0000-0003-4424-7569 UNSPECIFIED Langer, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Juergens, Herbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreyer, Justus UNSPECIFIED UNSPECIFIED UNSPECIFIED Vieth, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaefers, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Weckesser, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Hassenpflug, Wolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Corbacioglu, Selim UNSPECIFIED UNSPECIFIED UNSPECIFIED Bielack, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Mayer-Steinacker, Regina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuehne, Thomas UNSPECIFIED orcid.org/0000-0002-7387-7028 UNSPECIFIED van den Berg, Henk UNSPECIFIED UNSPECIFIED UNSPECIFIED Gelderblom, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Sebastian UNSPECIFIED orcid.org/0000-0001-5949-8120 UNSPECIFIED Stegger, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Dirksen, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-182342
DOI:	10.1002/pbc.27011
Journal or Publication Title:	Pediatr. Blood Cancer
Volume:	65
Number:	7
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1545-5017
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PULMONARY NODULES; SURVEILLANCE; TRIAL; PET/CT; TUMORS; CHEMOTHERAPY; TOMOGRAPHY; METASTASES; ONCOLOGY; OUTCOMES Multiple languages Oncology; Hematology; Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18234