Universität zu Köln

Schmack, Bastian, Grossekettler, Leonie, Weymann, Alexander, Schamroth, Joel, Sabashnikov, Anton, Raake, Philip W., Popov, Aron F., Mansur, Ashham, Karck, Matthias, Schwenger, Vedat and Ruhparwar, Arjang (2018). Prognostic relevance of hemodialysis for short-term survival in patients after LVAD implantation. Sci Rep, 8. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

End-stage heart failure (HF) is associated with renal failure (RF). This study aimed to determine the prognostic influence of RF and post-operative hemodialysis on short-term survival following left ventricular assist device (LVAD) implantation. This retrospective study includes 68 patients undergoing LVAD treatment. Kidney function was recorded prior to LVAD implantation, immediately afterwards and after 30 days, noting the need for hemodialysis. Median pre-operative Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) classification was 3.47 +/- 1.08. 30 days after implantation there was a significant improvement of estimated glomerular filtration rate (eGFR) and reduction of blood urea nitrogen (BUN). Of pre-operative RF parameters, BUN was associated with increased mortality and need for early post-operative hemodialysis. Post-operative hemodialysis was associated with significantly lower short-term survival, while pre-operative hemodialysis did not impact mortality. Post-operative acute kidney injury (AKI) requiring hemodialysis can be regarded as a strong negative prognostic marker for short-term survival. The absence of a clear correlation between most routine RF parameters and survival or the need for early post-operative hemodialysis calls into question the predictive value of pre-operative RE. The negative association of only post-operative hemodialysis on short-term survival emphasises the impact of the occurrence of AKI.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schmack, Bastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Grossekettler, Leonie UNSPECIFIED UNSPECIFIED UNSPECIFIED Weymann, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Schamroth, Joel UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabashnikov, Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Raake, Philip W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Popov, Aron F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mansur, Ashham UNSPECIFIED UNSPECIFIED UNSPECIFIED Karck, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwenger, Vedat UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhparwar, Arjang UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-183095
DOI:	10.1038/s41598-018-26515-0
Journal or Publication Title:	Sci Rep
Volume:	8
Date:	2018
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VENTRICULAR ASSIST DEVICE; RENAL-FUNCTION; HEART-FAILURE; THERAPY; SUPPORT Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18309