Universität zu Köln

Sommerauer, Michael, Hansen, Allan K., Parbo, Peter, Fedorova, Tatyana D., Knudsen, Karoline, Frederiksen, Yoon, Nahimi, Adjmal, Barbe, Michael T., Brooks, David J. and Borghammer, Per ORCID: 0000-0001-6391-8052 (2018). Decreased Noradrenaline Transporter Density in the Motor Cortex of Parkinson's Disease Patients. Mov. Disord., 33 (6). S. 1006 - 1010. HOBOKEN: WILEY. ISSN 1531-8257

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Abstract

Reduced noradrenaline levels have been reported to occur in the motor cortices of PD patients postmortem. Imaging techniques have recently become available to specifically study noradrenergic terminal function in vivo using PET. The objective of this study was to evaluate cortical C-11-MeNER binding in PD patients. Thirty PD patients and 12 healthy control subjects comparable in age, sex, and cognitive performance underwent PET imaging with C-11-MeNER, a specific ligand of the noradrenaline transporter. Cortical noradrenaline transporter binding was compared at a voxel level using Statistical Parametric Mapping, whereas cortical thickness was assessed using FreeSurfer software with MRI. PD patients showed reduced C-11-MeNER binding in the primary motor cortex unrelated to cortical thickness; other cortical regions did not differ between groups. In a subgroup analysis, patients with higher Hoehn & Yahr stage exhibited more pronounced C-11-MeNER binding reductions. Loss of cortical noradrenergic projections to the primary motor cortex occurs in PD associated with disease stage. (C) 2018 International Parkinson and Movement Disorder Society

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sommerauer, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Hansen, Allan K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Parbo, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Fedorova, Tatyana D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knudsen, Karoline UNSPECIFIED UNSPECIFIED UNSPECIFIED Frederiksen, Yoon UNSPECIFIED UNSPECIFIED UNSPECIFIED Nahimi, Adjmal UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbe, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brooks, David J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Borghammer, Per UNSPECIFIED orcid.org/0000-0001-6391-8052 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-183633
DOI:	10.1002/mds.27411
Journal or Publication Title:	Mov. Disord.
Volume:	33
Number:	6
Page Range:	S. 1006 - 1010
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1531-8257
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NOREPINEPHRINE TRANSPORTER; LOCUS-COERULEUS; SUBSTANTIA-NIGRA; CONTROLLED-TRIAL; MOUSE MODELS; L-DOPA; BRAIN; PET; METHYLPHENIDATE; SYMPTOMS Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18363