Universität zu Köln

Radunz, Lars, Reuter, Hannah and Andresen-Streichert, Hilke (2018). Modafinil in Forensic and Clinical Toxicology-Case Reports, Analytics and Literature. J. Anal. Toxicol., 42 (5). S. 353 - 360. CARY: OXFORD UNIV PRESS INC. ISSN 1945-2403

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Abstract

Modafinil is used because of its wakefulness-promoting properties for treatment of diseases associated with extreme sleepiness (i.e., narcolepsy). Additionally, it is misused as a cognitive enhancer to increase alertness and to improve concentration. We present modafinil concentrations in serum samples in five cases of our routine work measured by high-performance liquid chromatography coupled with a photo diode array detector after solid-phase extraction. One sample was analyzed for clinical toxicology purposes. The other four were investigated for the police: three cases of driving under the influence of drugs and one case of bodily harm. Sample preparation consisted of solid-phase extraction using Bond Elut (R) C18 columns. Papaverine was used as internal standard. Chromatographic separation was carried out using a Polaris C18-A column in an isocratic run. Wavelengths used for UV-detection were 220 nm for modafinil and 239 nm for the internal standard, respectively. The method was validated with a reduced validation design for rare analytes. A six-point-calibration from 0.5 to 5.0 mg/L, covering the therapeutic range (0.9-3.3 mg/L), was used for quantification. Concentrations in serum were in the range of 1.3 to similar to 34 mg/L (median: 3.6 mg/L; mean: 9.0 mg/L). To our knowledge, there are only few publications concerning the serum concentrations of modafinil in cases of (suspected) misuse, forensic cases or intoxications. In our discussion, the serum concentrations we determined are compared with the levels described in the literature so far.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Radunz, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Reuter, Hannah UNSPECIFIED UNSPECIFIED UNSPECIFIED Andresen-Streichert, Hilke UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-185134
DOI:	10.1093/jat/bky008
Journal or Publication Title:	J. Anal. Toxicol.
Volume:	42
Number:	5
Page Range:	S. 353 - 360
Date:	2018
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1945-2403
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIQUID-LIQUID-EXTRACTION; OPEN-LABEL; PHARMACOKINETICS; TABLETS; TOLERABILITY; SINGLE; ACID Multiple languages Chemistry, Analytical; Toxicology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18513