Universität zu Köln

Houbois, Christian, Haneder, Stefan, Merkt, Martin, Morelli, John N., Schmidt, Matthias, Hellmich, Martin, Mueller, Roman-Ulrich, Wahba, Roger, Maintz, David and Puesken, Michael (2018). Can computed tomography volumetry of the renal cortex replace MAG3-scintigraphy in all patients for determining split renal function? Eur. J. Radiol., 103. S. 105 - 112. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-7727

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Abstract

Objectives: The current gold standard for determination of split renal function (SRF) is Tc-99m-mercapto-acetyltriglycin (MAG3) scintigraphy. Initial studies comparing MAG3-scintigraphy and CT-based renal cortex volumetry (RCV) for calculation of SRF have shown similar results in highly selected patient collectives with normal renal function (i.e. living kidney donors). This study aims to compare MAG3-scintigraphy and CT-RCV within a large unselected patient collective including patients with impaired renal function. Materials and methods: For this assessment, 279 datasets (131 men, 148 women; mean age: 54.2 +/- 12.9 years, range: 24-84 years) of patients who underwent MAG3-scintigraphy and contrast-enhanced abdominal CT within two weeks were retrospectively analyzed. Two independent readers assessed the CT-RCV in all CT datasets using a semi-automated volumetry tool. The MAG3-scintigraphy and CT-RCV methods were compared, stratified for the eGFR. Statistical analysis included descriptive statistics as well as inter-observer agreement. Results: The absolute mean difference between the percentage contribution of the left and the right kidneys in total MAG3-clearance was 8.6%. Independent of eGFR, an overall sufficient agreement between both methods was established in all patients. A relatively small, tolerable systemic error resulted in an underestimation (max. 2%) of the left renal contribution to overall RCV. Conclusion: The results demonstrate that CT-RCV is a potential clinical replacement for MAG3-scintigraphy for calculation of SRF: CT-RCV demonstrates clinically tolerable differences with MAG3-scintigraphy, independent of patient eGFR. The relative complexity of the RCV method utilized is a potential limitation and may have contributed to the acceptable but only fair to moderate level of intra-reader reliability.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Houbois, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Haneder, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Merkt, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Morelli, John N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Roman-Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahba, Roger UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Puesken, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-185252
DOI:	10.1016/j.ejrad.2018.04.016
Journal or Publication Title:	Eur. J. Radiol.
Volume:	103
Page Range:	S. 105 - 112
Date:	2018
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-7727
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIVING KIDNEY DONORS; GAMMA-CAMERA RENOGRAPHY; SCINTIGRAPHY; SCANS Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18525