Universität zu Köln

Talhada, Daniela ORCID: 0000-0002-5424-1438, Rabenstein, Monika and Ruscher, Karsten ORCID: 0000-0001-7211-2499 (2018). The role of dopaminergic immune cell signalling in poststroke inflammation. Ther. Adv. Neurol. Disord., 11. LONDON: SAGE PUBLICATIONS LTD. ISSN 1756-2864

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Abstract

Upon ischaemic stroke, brain-resident and peripheral immune cells accumulate in the central nervous system (CNS). Interestingly, these cells express pattern specific to neurotransmitter receptors and, therefore, seem to be susceptible to neurotransmitter stimulation, potentially modulating their properties and functions. One of the principal neurotransmitters in the CNS, dopamine, is involved in the regulation of processes of brain development, motor control and higher brain functions. It is constantly released in the brain and there is experimental and clinical evidence that dopaminergic signalling is involved in recovery of lost neurological function after stroke. Independent studies have revealed specific but different patterns of dopamine receptor subtypes on different populations of immune cells. Those patterns are dependent on the activation status of cells. Generally, exposure to dopamine or dopamine receptor agonists decreases detrimental actions of immune cells. In contrast, a reduction of dopaminergic inputs perpetuates a pro-inflammatory state associated with increased release of pro-inflammatory molecules. In addition, subsets of immune cells have been identified to synthesize and release dopamine, suggesting autoregulatory mechanisms. Evidence supports that inflammatory processes activated following ischaemic stroke are modulated by dopaminergic signalling.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Talhada, Daniela UNSPECIFIED orcid.org/0000-0002-5424-1438 UNSPECIFIED Rabenstein, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruscher, Karsten UNSPECIFIED orcid.org/0000-0001-7211-2499 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-186514
DOI:	10.1177/1756286418774225
Journal or Publication Title:	Ther. Adv. Neurol. Disord.
Volume:	11
Date:	2018
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	1756-2864
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PERIPHERAL-BLOOD LYMPHOCYTES; IMPROVES FUNCTIONAL RECOVERY; RADIOLIGAND BINDING ASSAY; LIMIT CNS INFLAMMATION; RECEPTOR MESSENGER-RNA; REGULATORY T-CELLS; EXPERIMENTAL STROKE; INTERFERON-GAMMA; DENDRITIC CELLS; RAT-BRAIN Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18651