Bavinck, Jan N. Bouwes, Feltkamp, Mariet C. W., Green, Adele C., Fiocco, Marta, Euvrard, Sylvie, Harwood, Catherine A., Nasir, Shaaira, Thomson, Jason ORCID: 0000-0002-6644-0979, Proby, Charlotte M., Naldi, Luigi ORCID: 0000-0002-3160-2835, Diphoorn, Janouk C. D., Venturuzzo, Anna, Tessari, Gianpaolo, Nindl, Ingo, Sampogna, Francesca ORCID: 0000-0002-7624-3290, Abeni, Damiano, Neale, Rachel E. ORCID: 0000-0001-7162-0854, Goeman, Jelle J., Quint, Koen D., Halk, Anne B., Sneek, Carmen, Genders, Roel E., de Koning, Maurits N. C., Quint, Wim G. V., Wieland, Ulrike, Weissenborn, Soenke, Waterboer, Tim, Pawlita, Michael and Pfister, Herbert (2018). Human papillomavirus and posttransplantation cutaneous squamous cell carcinoma: A multicenter, prospective cohort study. Am. J. Transplant., 18 (5). S. 1220 - 1231. HOBOKEN: WILEY. ISSN 1600-6143

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Abstract

Organ transplant recipients (OTRs) have a 100-fold increased risk of cutaneous squamous cell carcinoma (cSCC). We prospectively evaluated the association between genus human papillomaviruses (PV) and keratinocyte carcinoma in OTRs. Two OTR cohorts without cSCC were assembled: cohort 1 was transplanted in 2003-2006 (n =274) and cohort 2 was transplanted in 1986-2002 (n =352). Participants were followed until death or cessation of follow-up in 2016. PV infection was assessed in eyebrow hair by using polymerase chain reaction-based methods. PV IgG seroresponses were determined with multiplex serology. A competing risk model with delayed entry was used to estimate cumulative incidence of histologically proven cSCC and the effect of PV by using a multivariable Cox regression model. Results are reported as adjusted hazard ratios (HRs). OTRs with 5 or more different PV types in eyebrow hair had 1.7 times the risk of cSCC vs OTRs with 0 to 4 different types (HR 1.7, 95% confidence interval 1.1-2.6). A similar risk was seen with high PV loads (HR 1.8, 95% confidence interval 1.2-2.8). No significant associations were seen between serum antibodies and cSCC or between PV and basal cell carcinoma. The diversity and load of PV types in eyebrow hair are associated with cSCC risk in OTRs, providing evidence that PV is associated with cSCC carcinogenesis and may present a target for future preventive strategies. In two cohorts of organ transplant recipients, those with five and more different beta-genus human papillomavirus types and high virus loads in eyebrow hairs subsequently develop significantly more cutaneous squamous cell carcinomas than others, suggesting that these virus types may increase the risk of cutaneous squamous cell carcinoma in these patients.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bavinck, Jan N. BouwesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feltkamp, Mariet C. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Green, Adele C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fiocco, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Euvrard, SylvieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harwood, Catherine A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nasir, ShaairaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thomson, JasonUNSPECIFIEDorcid.org/0000-0002-6644-0979UNSPECIFIED
Proby, Charlotte M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Naldi, LuigiUNSPECIFIEDorcid.org/0000-0002-3160-2835UNSPECIFIED
Diphoorn, Janouk C. D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Venturuzzo, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tessari, GianpaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nindl, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sampogna, FrancescaUNSPECIFIEDorcid.org/0000-0002-7624-3290UNSPECIFIED
Abeni, DamianoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neale, Rachel E.UNSPECIFIEDorcid.org/0000-0001-7162-0854UNSPECIFIED
Goeman, Jelle J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quint, Koen D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Halk, Anne B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sneek, CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Genders, Roel E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Koning, Maurits N. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quint, Wim G. V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wieland, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weissenborn, SoenkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waterboer, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pawlita, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfister, HerbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-186750
DOI: 10.1111/ajt.14537
Journal or Publication Title: Am. J. Transplant.
Volume: 18
Number: 5
Page Range: S. 1220 - 1231
Date: 2018
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1600-6143
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ORGAN-TRANSPLANT RECIPIENTS; NONMELANOMA SKIN-CANCER; BETAPAPILLOMAVIRUS INFECTION; BASAL-CELL; RISK; SEROPOSITIVITY; ASSOCIATION; BETA; NETHERLANDS; MICROBIOMEMultiple languages
Surgery; TransplantationMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18675

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