Universität zu Köln

Becker, Christina, Kukat, Alexandra, Szczepanowska, Karolina, Hermans, Steffen, Senft, Katharina, Brandscheid, Christoph Paul, Maiti, Priyanka ORCID: 0000-0003-4207-0341 and Trifunovic, Aleksandra ORCID: 0000-0002-5472-3517 (2018). CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis. EMBO Rep., 19 (5). HOBOKEN: WILEY. ISSN 1469-3178

Full text not available from this repository.

Abstract

Mitochondria are fundamental for cellular metabolism as they are both a source and a target of nutrient intermediates originating from converging metabolic pathways, and their role in the regulation of systemic metabolism is increasingly recognized. Thus, maintenance of mitochondrial homeostasis is indispensable for a functional energy metabolism of the whole organism. Here, we report that loss of the mitochondrial matrix protease CLPP results in a lean phenotype with improved glucose homeostasis. Whole-body CLPP-deficient mice are protected from diet-induced obesity and insulin resistance, which was not present in mouse models with either liver- or muscle-specific depletion of CLPP. However, CLPP ablation also leads to a decline in brown adipocytes function leaving mice unable to cope with a cold-induced stress due to non-functional adaptive thermogenesis. These results demonstrate a critical role for CLPP in different metabolic stress conditions such as high-fat diet feeding and cold exposure providing tools to understand pathologies with deregulated Clpp expression and novel insights into therapeutic approaches against metabolic dysfunctions linked to mitochondrial diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Becker, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kukat, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Szczepanowska, Karolina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hermans, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Senft, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Brandscheid, Christoph Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Maiti, Priyanka UNSPECIFIED orcid.org/0000-0003-4207-0341 UNSPECIFIED Trifunovic, Aleksandra UNSPECIFIED orcid.org/0000-0002-5472-3517 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-186865
DOI:	10.15252/embr.201745126
Journal or Publication Title:	EMBO Rep.
Volume:	19
Number:	5
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1469-3178
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FATTY-ACID OXIDATION; INSULIN-RESISTANCE; POLYMERASE-GAMMA; SKELETAL-MUSCLE; MICE; OBESITY; MTDNA; DYSFUNCTION; EXPRESSION; MUTATIONS Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18686