Universität zu Köln

Magni, Stefano ORCID: 0000-0001-8649-3616, Succurro, Antonella ORCID: 0000-0003-0227-2803, Skupin, Alexander and Ebenhoeh, Oliver ORCID: 0000-0002-7229-7398 (2018). Data-driven dynamical model indicates that the heat shock response in Chlamydomonas reinhardtii is tailored to handle natural temperature variation. J. R. Soc. Interface, 15 (142). LONDON: ROYAL SOC. ISSN 1742-5662

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Abstract

Global warming exposes plants to severe heat stress, with consequent crop yield reduction. Organisms exposed to high temperature stresses typically protect themselves with a heat shock response (HSR), where accumulation of unfolded proteins initiates the synthesis of heat shock proteins through the heat shock transcription factor HSF1. While the molecular mechanisms are qualitatively well characterized, our quantitative understanding of the underlying dynamics is still very limited. Here, we study the dynamics of HSR in the photosynthetic model organism Chlamydomonas reinhardtii with a data-driven mathematical model of HSR. We based our dynamical model mostly on mass action kinetics, with a few nonlinear terms. The model was parametrized and validated by several independent datasets obtained from the literature. We demonstrate that HSR quantitatively and significantly differs if an increase in temperature of the same magnitude occurs abruptly, as often applied under laboratory conditions, or gradually, which would rather be expected under natural conditions. In contrast to rapid temperature increases, under gradual changes only negligible amounts of misfolded proteins accumulate, indicating that the HSR of C. reinhardtii efficiently avoids the accumulation of misfolded proteins under conditions most likely to prevail in nature. The mathematical model we developed is a flexible tool to simulate the HSR to different conditions and complements the current experimental approaches.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Magni, Stefano UNSPECIFIED orcid.org/0000-0001-8649-3616 UNSPECIFIED Succurro, Antonella UNSPECIFIED orcid.org/0000-0003-0227-2803 UNSPECIFIED Skupin, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Ebenhoeh, Oliver UNSPECIFIED orcid.org/0000-0002-7229-7398 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-187046
DOI:	10.1098/rsif.2017.0965
Journal or Publication Title:	J. R. Soc. Interface
Volume:	15
Number:	142
Date:	2018
Publisher:	ROYAL SOC
Place of Publication:	LONDON
ISSN:	1742-5662
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STRESS-RESPONSE; MATHEMATICAL-MODEL; ESCHERICHIA-COLI; CIRCADIAN CLOCK; PROTEINS; HSP90; ARABIDOPSIS; CHAPERONE; PROMOTER; REVEALS Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18704