Universität zu Köln

Verger, Antoine, Filss, Christian P., Lohmann, Philipp ORCID: 0000-0002-5360-046X, Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Sabel, Michael, Wittsack, Hans-J., Kops, Elena Rota, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Shah, Nadim J. and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2018). Comparison of O-(2-F-18-Fluoroethyl)-L-Tyrosine Positron Emission Tomography and Perfusion-Weighted Magnetic Resonance Imaging in the Diagnosis of Patients with Progressive and Recurrent Glioma: A Hybrid Positron Emission Tomography/Magnetic Resonance Study. World Neurosurg., 113. S. E727 - 11. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1878-8769

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Abstract

OBJECTIVE: To compare the diagnostic performance of O-(2-F-18-fluoroethyl)-L-tyrosine (F-18-FET) positron emission tomography (PET) and perfusion-weighted magnetic resonance imaging (PWI) for the diagnosis of progressive or recurrent glioma. METHODS: Thirty-two pretreated gliomas (25 progressive or recurrent tumors, 7 treatment-related changes) were investigated with F-18-FET PET and PWI via a hybrid PET/magnetic resonance scanner. Volumes of interest with a diameter of 16 mm were centered on the maximum of abnormality in the tumor area in PET and PWI maps (relative cerebral blood volume, relative cerebral blood flow, mean transit time) and the contralateral unaffected hemisphere. Mean and maximum tumor-to-brain ratios as well as dynamic data for F-18-FET uptake were calculated. Diagnostic accuracies were evaluated by receiver operating characteristic analyses, calculating the area under the curve. RESULTS: F-18-FET PET showed a significant greater sensitivity to detect abnormalities in pretreated gliomas than PWI (76% vs. 52%, P = 0.03). The maximum tumorto-brain ratio of F-18-FET PET was the only parameter that discriminated treatment-related changes from progressive or recurrent gliomas (area under the curve, 0.78; P = 0.03, best cut-off 2.61; sensitivity 80%, specificity 86%, accuracy 81%). Among patients with signal abnormality in both modalities, 75% revealed spatially incongruent local hot spots. CONCLUSIONS: This pilot study suggests that F-18-FET PET is superior to PWI to diagnose progressive or recurrent glioma.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Verger, Antoine UNSPECIFIED UNSPECIFIED UNSPECIFIED Filss, Christian P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lohmann, Philipp UNSPECIFIED orcid.org/0000-0002-5360-046X UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Sabel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittsack, Hans-J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kops, Elena Rota UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Shah, Nadim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-187191
DOI:	10.1016/j.wneu.2018.02.139
Journal or Publication Title:	World Neurosurg.
Volume:	113
Page Range:	S. E727 - 11
Date:	2018
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1878-8769
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CEREBRAL BLOOD-VOLUME; HIGH-GRADE GLIOMAS; RADIATION NECROSIS; F-18-FET PET; C-11-METHIONINE PET; RESPONSE ASSESSMENT; TUMOR RECURRENCE; MRI; PARAMETERS; ACCURACY Multiple languages Clinical Neurology; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18719