Universität zu Köln

Lohneis, Philipp, Sinn, Marianne, Klein, Fritz, Bischoff, Sven, Striefler, Jana K., Wislocka, Lilianna, Sinn, Bruno V., Pelzer, Uwe ORCID: 0000-0001-9213-2737, Oettle, Helmut, Riess, Hanno, Denkert, Carsten, Blaeker, Hendrik and Juehling, Anja (2018). Tumour buds determine prognosis in resected pancreatic ductal adenocarcinoma. Br. J. Cancer, 118 (11). S. 1485 - 1492. LONDON: NATURE PUBLISHING GROUP. ISSN 1532-1827

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Abstract

BACKGROUND: The prognostic effect of tumour budding was retrospectively analysed in a cohort of 173 patients with resected pancreatic ductal adenocarcinomas (PDACs) of the prospective clinical multicentre CONKO-001 trial. METHODS: Haematoxylin and eosin (H&E)-stained whole tissue slides were evaluated. In two independent approaches, the mean number of tumour buds was analysed according to the consensus criteria in colorectal cancer, in one 0.785 mm(2) field of view and additionally in 10 high-power fields (HPF) (HPF = 0.238 mm(2)). RESULTS: Tumour budding was significantly associated with a higher tumour grade (p < 0.001) but not with distant or lymph node metastasis. Regardless of the quantification approach, an increased number of tumour buds was significantly associated with reduced disease-free survival (DFS) and overall survival (OS) (10 HPF approach DFS: HR = 1.056 (95% CI 1.022-1.092), p = 0.001; OS: HR = 1.052 (95% CI 1.018-1.087), p = 0.002; consensus method DFS: HR = 1.037 (95% CI 1.017-1.058), p < 0.001; OS: HR = 1.040 (95% CI 1.019-1.061), p < 0.001). Recently published cut-offs for tumour budding in colorectal cancer were prognostic in PDAC as well. CONCLUSIONS: Tumour budding is prognostic in the CONKO-001 clinical cohort of patients. Further standardisation and validation in additional clinical cohorts are necessary.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lohneis, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Sinn, Marianne UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Fritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Bischoff, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Striefler, Jana K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wislocka, Lilianna UNSPECIFIED UNSPECIFIED UNSPECIFIED Sinn, Bruno V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pelzer, Uwe UNSPECIFIED orcid.org/0000-0001-9213-2737 UNSPECIFIED Oettle, Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Riess, Hanno UNSPECIFIED UNSPECIFIED UNSPECIFIED Denkert, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Blaeker, Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Juehling, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-187470
DOI:	10.1038/s41416-018-0093-y
Journal or Publication Title:	Br. J. Cancer
Volume:	118
Number:	11
Page Range:	S. 1485 - 1492
Date:	2018
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1532-1827
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EPITHELIAL-MESENCHYMAL TRANSITION; LYMPH-NODE; ADJUVANT CHEMOTHERAPY; POOR-PROGNOSIS; INVASIVE FRONT; CANCER; ESOPHAGEAL; PREDICTS; FEATURES; RECOMMENDATIONS Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18747