Universität zu Köln

Eminaga, O., Li, S., Baker, L. C., Brooks, J. D. and Eisenberg, M. L. (2018). Male infertility is associated with altered treatment course of men with cancer. Andrology, 6 (3). S. 408 - 414. HOBOKEN: WILEY. ISSN 2047-2927

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Abstract

This study aims to evaluate whether cancer treatments differ in infertile men compared to men who have undergone vasectomy and age-matched controls. We analyzed subjects from the Truven Health MarketScan Claims database from 2001 to 2009. Infertile men were identified through diagnosis and treatment codes. Comparison groups included vasectomized men and an age-matched cohort who were not infertile and had not undergone vasectomy. We considered cancer types previously associated with infertility that were diagnosed after the diagnosis of infertility. The treatment regimens were determined based on the presence of claims with CPT codes for chemotherapy (CTX), radiation (RTX) or surgical treatment (ST) for each entity in all study groups. Cases with multimodal treatments were also identified. As a result, CTX was similarly distributed among the infertile, vasectomized, and control groups. In contrast, RTX treatment length was shorter in infertile men. The frequency of multimodal treatment (i.e., radiation and chemotherapy) was twofold lower in men with infertility compared to other men. By focusing on treatment patterns for each cancer type among these groups, the duration of RTX and CTX was shorter in infertile men diagnosed with NHL compared to controls. We conclude that Infertile men diagnosed with cancer and specific cancer types experience different treatment courses, with shorter RTX and less combined RTX/CTX compared to fertile and vasectomized men. These differences could reflect differences in stage at presentation, biological behavior, or treatment responses in infertile men.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eminaga, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baker, L. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brooks, J. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eisenberg, M. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-187495
DOI:	10.1111/andr.12472
Journal or Publication Title:	Andrology
Volume:	6
Number:	3
Page Range:	S. 408 - 414
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	2047-2927
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NON-HODGKINS-LYMPHOMA; PROSTATE-CANCER; TESTICULAR CANCER; INCREASED RISK; BCL-2; SPERMATOGENESIS; MANAGEMENT; QUALITY; UPDATE; COHORT Multiple languages Andrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18749