Universität zu Köln

Liedtke, J. -P., Mandl, A., Koether, J., Chwieralski, J., Shah-Hosseini, K., Raskopf, E., Pieper-Fuerst, U., Allekotte, S. and Moesges, R. (2018). RCAT reflects symptom control and quality of life in allergic rhinoconjunctivitis patients. Allergy, 73 (5). S. 1101 - 1110. HOBOKEN: WILEY. ISSN 1398-9995

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Abstract

BackgroundThe Global Allergy and Asthma European Network (GA(2)LEN) Taskforce has requested more data on correlations between various patient-reported outcomes (PROs) in clinical trials on allergy. We compared three toolsthe Rhinitis Control Assessment Test (RCAT), Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) and Rhinitis Total Symptom Score (RTSS)to determine whether the RCAT alone is a sufficient primary outcome parameter in clinical trials on allergic rhinoconjunctivitis. MethodsIn two double-blind, placebo-controlled immunotherapy studies, 33 patients allergic to grass pollen and 94 to birch pollen completed two questionnaires (RCAT and RQLQ) and kept their own symptom diary from which the RTSS was calculated. ResultsUpon comparing RCAT and RQLQ results, we found strong correlations of r = -0.871 for grass pollen-allergic patients and r = -0.795 for birch pollen-allergic patients. The comparison between RCAT and RTSS results showed a strong correlation of r = -0.811 (grass pollen-allergic patients) and a moderate correlation of r = -0.539 (birch pollen-allergic patients). In the RCAT, 69.7% of grass pollen-allergic patients and 45.7% of birch pollen-allergic patients receiving guideline-concordant therapy were regarded as having insufficiently controlled symptoms. ConclusionThe strong correlations suggest that the RCAT alone is equivalent to the RQLQ with respect to patients' symptom control and quality of life. Patients with uncontrolled symptoms can be identified using the RCAT. Hence, the physician can decide whether symptomatic therapy can be intensified or allergy immunotherapy should be administered.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Liedtke, J. -P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mandl, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koether, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chwieralski, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah-Hosseini, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Raskopf, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pieper-Fuerst, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Allekotte, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moesges, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-188170
DOI:	10.1111/all.13362
Journal or Publication Title:	Allergy
Volume:	73
Number:	5
Page Range:	S. 1101 - 1110
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1398-9995
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TASKFORCE POSITION PAPER; BECLOMETHASONE DIPROPIONATE; RANDOMIZED-TRIAL; RHINITIS CONTROL; CLINICAL-TRIALS; ARIA GUIDELINES; ASTHMA CONTROL; UNITED-STATES; IMMUNOTHERAPY; QUESTIONNAIRE Multiple languages Allergy; Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18817