Stecher, Melanie, Chaillon, Antoine, Eberle, Josef, Behrens, Georg M. N., Eis-Huebinger, Anna-Maria, Lehmann, Clara, Jablonka, Alexandra, Bogner, Johannes, Faetkenheuer, Gerd, Spinner, Christoph D., Wasmuth, Jan-Christian, Kaiser, Rolf, Mehta, Sanjay R., Vehreschild, Joerg Janne and Hoenigl, Martin ORCID: 0000-0002-1653-2824 (2018). Molecular Epidemiology of the HIV Epidemic in Three German Metropolitan Regions - Cologne/Bonn, Munich and Hannover, 1999-2016. Sci Rep, 8. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Using HIV sequence data to characterize clusters of HIV transmission may provide insight into the epidemic. Phylogenetic and network analyses were performed to infer putative relationships between HIV-1 partial pol sequences from 2,774 individuals receiving care in three German regions between 1999-2016. The regions have in common that they host some of the largest annual festivals in Europe (Carnival and Oktoberfest). Putative links with sequences (n = 150,396) from the Los Alamos HIV Sequence database were evaluated. A total of 595/2,774 (21.4%) sequences linked with at least one other sequence, forming 184 transmission clusters. Clustering individuals were significantly more likely to be younger, male, and report sex with men as their main risk factor (p < 0.001 each). Most clusters (77.2%) consisted exclusively of men; 41 (28.9%) of these included men reporting sex with women. Thirty-two clusters (17.4%) contained sequences from more than one region; clustering men were significantly more likely to be in a position bridging regional HIV epidemics than clustering women (p = 0.027). We found 236 clusters linking 547 sequences from our sample with sequences from the Los Alamos database (n = 1407; 31% from other German centres). These results highlight the pitfalls of focusing HIV prevention efforts on specific risk groups or specific locales.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Stecher, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chaillon, AntoineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eberle, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Behrens, Georg M. N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eis-Huebinger, Anna-MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehmann, ClaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jablonka, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bogner, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faetkenheuer, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spinner, Christoph D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wasmuth, Jan-ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, RolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mehta, Sanjay R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Joerg JanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoenigl, MartinUNSPECIFIEDorcid.org/0000-0002-1653-2824UNSPECIFIED
URN: urn:nbn:de:hbz:38-188444
DOI: 10.1038/s41598-018-25004-8
Journal or Publication Title: Sci Rep
Volume: 8
Date: 2018
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2045-2322
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SEXUAL-RISK BEHAVIOR; TRANSMISSION NETWORKS; SAN-DIEGO; YOUNG MEN; INFECTION; EUROPEMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18844

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