Universität zu Köln

Schommers, Philipp ORCID: 0000-0003-3375-6800, Gillor, Daniel, Hentrich, Marcus, Wyen, Christoph, Wolf, Timo, Oette, Mark, Zoufaly, Alexander, Wasmuth, Jan-Christian, Bogner, Johannes R., Mueller, Markus, Esser, Stefan, Schleicher, Alisa, Jensen, Bjoern, Stoehr, Albrecht, Behrens, Georg, Schultze, Alexander, Siehl, Jan, Thoden, Jan, Taylor, Ninon and Hoffmann, Christian (2018). Incidence and risk factors for relapses in HIV-associated non-Hodgkin lymphoma as observed in the German HIV-related lymphoma cohort study. Haematologica, 103 (5). S. 857 - 865. PAVIA: FERRATA STORTI FOUNDATION. ISSN 0390-6078

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Abstract

Outcome of HIV-infected patients with AIDS-related lymphomas has improved during recent years. However, data on incidence, risk factors, and outcome of relapses in AIDS-related lymphomas after achieving complete remission are still limited. This prospective observational multicenter study includes HIV-infected patients with biopsy-or cytology-proven malignant lymphomas since 2005. Data on HIV infection and lymphoma characteristics, treatment and outcome were recorded. For this analysis, AIDS-related lymphomas patients in complete remission were analyzed in terms of their relapse-free survival and potential risk factors for relapses. In total, 254 of 399 (63.7%) patients with AIDS-related lymphomas reached a complete remission with their first-line chemotherapy. After a median follow up of 4.6 years, 5-year overall survival of the 254 patients was 87.8% (Standard Error 3.1%). Twenty-nine patients relapsed (11.4%). Several factors were independently associated with a higher relapse rate, including an unclassifiable histology, a stage III or IV according to the Ann Arbor Staging System, no concomitant combined antiretroviral therapy during chemotherapy and R-CHOP-based compared to more intensive chemotherapy regimens in Burkitt lymphomas. In conclusion, complete remission and relapse rates observed in our study are similar to those reported in HIV-negative non-Hodgkin lymphomas. These data provide further evidence for the use of concomitant combined antiretroviral therapy during chemotherapy and a benefit from more intensive chemotherapy regimens in Burkitt lymphomas. Modifications to the chemotherapy regimen appear to have only a limited impact on relapse rate.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schommers, Philipp UNSPECIFIED orcid.org/0000-0003-3375-6800 UNSPECIFIED Gillor, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Hentrich, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED Wyen, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Oette, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoufaly, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Wasmuth, Jan-Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Bogner, Johannes R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Esser, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Schleicher, Alisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Jensen, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoehr, Albrecht UNSPECIFIED UNSPECIFIED UNSPECIFIED Behrens, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Schultze, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Siehl, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Thoden, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Taylor, Ninon UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-188929
DOI:	10.3324/haematol.2017.180893
Journal or Publication Title:	Haematologica
Volume:	103
Number:	5
Page Range:	S. 857 - 865
Date:	2018
Publisher:	FERRATA STORTI FOUNDATION
Place of Publication:	PAVIA
ISSN:	0390-6078
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language B-CELL LYMPHOMA; AIDS-RELATED LYMPHOMA; QUANTITATIVE FDG-PET; PLASMABLASTIC LYMPHOMA; MALIGNANT-LYMPHOMA; RESPONSE CRITERIA; INFECTED PATIENTS; DOSE INTENSITY; WORKING GROUP; OPEN-LABEL Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18892