Universität zu Köln

Schiffer, Philipp H., Polsky, Avital L., Cole, Alison G. ORCID: 0000-0002-7515-7489, Camps, Julia I. R., Kroiher, Michael, Silver, David H., Grishkevich, Vladislav, Anavy, Leon ORCID: 0000-0002-6681-7377, Koutsovoulos, Georgios, Hashimshony, Tamar and Yanai, Itai ORCID: 0000-0002-8438-2741 (2018). The gene regulatory program of Acrobeloides nanus reveals conservation of phylum-specific expression. Proc. Natl. Acad. Sci. U. S. A., 115 (17). S. 4459 - 4465. WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

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Abstract

The evolution of development has been studied through the lens of gene regulation by examining either closely related species or extremely distant animals of different phyla. In nematodes, detailed cell-and stage-specific expression analyses are focused on the model Caenorhabditis elegans, in part leading to the view that the developmental expression of gene cascades in this species is archetypic for the phylum. Here, we compared two species of an intermediate evolutionary distance: the nematodes C. elegans (clade V) and Acrobeloides nanus (clade IV). To examine A. nanus molecularly, we sequenced its genome and identified the expression profiles of all genes throughout embryogenesis. In comparison with C. elegans, A. nanus exhibits a much slower embryonic development and has a capacity for regulative compensation of missing early cells. We detected conserved stages between these species at the transcriptome level, as well as a prominent middevelopmental transition, at which point the two species converge in terms of their gene expression. Interestingly, we found that genes originating at the dawn of the Ecdysozoa super-group show the least expression divergence between these two species. This led us to detect a correlation between the time of expression of a gene and its phylogenetic age: evolutionarily ancient and young genes are enriched for expression in early and late embryogenesis, respectively, whereas Ecdysozoa-specific genes are enriched for expression during the middevelopmental transition. Our results characterize the developmental constraints operating on each individual embryo in terms of developmental stages and genetic evolutionary history.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schiffer, Philipp H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Polsky, Avital L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cole, Alison G. UNSPECIFIED orcid.org/0000-0002-7515-7489 UNSPECIFIED Camps, Julia I. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroiher, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Silver, David H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grishkevich, Vladislav UNSPECIFIED UNSPECIFIED UNSPECIFIED Anavy, Leon UNSPECIFIED orcid.org/0000-0002-6681-7377 UNSPECIFIED Koutsovoulos, Georgios UNSPECIFIED UNSPECIFIED UNSPECIFIED Hashimshony, Tamar UNSPECIFIED UNSPECIFIED UNSPECIFIED Yanai, Itai UNSPECIFIED orcid.org/0000-0002-8438-2741 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-189107
DOI:	10.1073/pnas.1720817115
Journal or Publication Title:	Proc. Natl. Acad. Sci. U. S. A.
Volume:	115
Number:	17
Page Range:	S. 4459 - 4465
Date:	2018
Publisher:	NATL ACAD SCIENCES
Place of Publication:	WASHINGTON
ISSN:	0027-8424
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSPOSABLE ELEMENTS; LIFE-HISTORY; BODY PLANS; RNA-SEQ; EVOLUTION; NEMATODES; EMBRYOS; EMBRYOGENESIS; DIVERGENCE; PATTERNS Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18910