Universität zu Köln

Genon, Sarah, Reid, Andrew ORCID: 0000-0002-0523-926X, Li, Hai, Fan, Lingzhong, Mueller, Veronika I., Cieslik, Edna C., Hoffstaedter, Felix ORCID: 0000-0001-7163-3110, Langner, Robert ORCID: 0000-0002-3237-001X, Grefkes, Christian ORCID: 0000-0002-1656-720X, Laird, Angela R., Fox, Peter T., Jiang, Tianzi ORCID: 0000-0001-9531-291X, Amunts, Katrin and Eickhoff, Simon B. ORCID: 0000-0001-6363-2759 (2018). The heterogeneity of the left dorsal premotor cortex evidenced by multimodal connectivity-based parcellation and functional characterization. Neuroimage, 170. S. 400 - 412. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

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Abstract

Despite the common conception of the dorsal premotor cortex (PMd) as a single brain region, its diverse connectivity profiles and behavioral heterogeneity argue for a differentiated organization of the PMd. A previous study revealed that the right PMd is characterized by a rostro-caudal and a ventro-dorsal distinction dividing it into five subregions: rostral, central, caudal, ventral and dorsal. The present study assessed whether a similar organization is present in the left hemisphere, by capitalizing on a multimodal data-driven approach combining connectivity-based parcellation (CBP) based on meta-analytic modeling, resting-state functional connectivity, and probabilistic diffusion tractography. The resulting PMd modules were then characterized based on multimodal functional connectivity and a quantitative analysis of associated behavioral functions. Analyzing the clusters consistent across all modalities revealed an organization of the left PMd that mirrored its right counterpart to a large degree. Again, caudal, central and rostral modules reflected a cognitive-motor gradient and a premotor eye-field was found in the ventral part of the left PMd. In addition, a distinct module linked to abstract cognitive functions was observed in the rostro-ventral left PMd across all CBP modalities, implying greater differentiation of higher cognitive functions for the left than the right PMd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Genon, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Reid, Andrew UNSPECIFIED orcid.org/0000-0002-0523-926X UNSPECIFIED Li, Hai UNSPECIFIED UNSPECIFIED UNSPECIFIED Fan, Lingzhong UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Veronika I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cieslik, Edna C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffstaedter, Felix UNSPECIFIED orcid.org/0000-0001-7163-3110 UNSPECIFIED Langner, Robert UNSPECIFIED orcid.org/0000-0002-3237-001X UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED Laird, Angela R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fox, Peter T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jiang, Tianzi UNSPECIFIED orcid.org/0000-0001-9531-291X UNSPECIFIED Amunts, Katrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-189297
DOI:	10.1016/j.neuroimage.2017.02.034
Journal or Publication Title:	Neuroimage
Volume:	170
Page Range:	S. 400 - 412
Date:	2018
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACTIVATION-BASED PARCELLATION; PRIMARY MOTOR CORTEX; ROSTRO-CAUDAL AXIS; INTERINDIVIDUAL VARIABILITY; MACAQUE MONKEY; HUMAN BRAIN; PARIETAL CORTEX; FRONTAL-CORTEX; AREAS; METAANALYSIS Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18929