Universität zu Köln

Cordina-Duverger, Emilie, Menegaux, Florence ORCID: 0000-0003-3363-6411, Popa, Alexandru, Rabstein, Sylvia, Harth, Volker, Pesch, Beate, Bruening, Thomas, Fritschi, Lin ORCID: 0000-0002-7692-3560, Glass, Deborah C., Heyworth, Jane S., Erren, Thomas C., Castano-Vinyals, Gemma ORCID: 0000-0003-4468-1816, Papantoniou, Kyriaki, Espinosa, Ana, Kogevinas, Manolis ORCID: 0000-0002-9605-0461, Grundy, Anne, Spinelli, John J. ORCID: 0000-0002-9119-3287, Aronson, Kristan J. and Guenel, Pascal ORCID: 0000-0002-8359-518X (2018). Night shift work and breast cancer: a pooled analysis of population-based case-control studies with complete work history. Eur. J. Epidemiol., 33 (4). S. 369 - 380. DORDRECHT: SPRINGER. ISSN 1573-7284

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Abstract

Night shift work has been suspected to increase breast cancer risk but epidemiological studies have been inconsistent due to heterogeneous assessment of exposure to night work. To overcome this limitation, we pooled data of five population-based case-control studies from Australia, Canada, France, Germany, and Spain into a single harmonized dataset using a common definition of night work including 6093 breast cancer cases and 6933 population controls. The odds ratio for breast cancer in women who ever worked at night for at least 3 h between midnight and 5 a. m. as compared to never night workers was 1.12 (95% CI 1.00-1.25). Among pre-menopausal women, this odds ratio was 1.26 [1.06-1.51], increasing to 1.36 [1.07-1.74] for night shifts >= 10 h, 1.80 [1.20-2.71] for work >= 3 nights/week, and 2.55 [1.03-6.30] for both duration of night work >= 10 years and exposure intensity >= 3 nights/week. Breast cancer risk in pre-menopausal women was higher in current or recent night workers (OR = 1.41 [1.06-1.88]) than in those who had stopped night work more than 2 years ago. Breast cancer in post-menopausal women was not associated with night work whatever the exposure metric. The increase in risk was restricted to ER+ tumors, particularly those who were both ER+ and HER2+. These results support the hypothesis that night shift work increases the risk of breast cancer in pre-menopausal women, particularly those with high intensity and long duration of exposure. Risk difference between pre-and post-menopausal women deserves further scrutiny.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cordina-Duverger, Emilie UNSPECIFIED UNSPECIFIED UNSPECIFIED Menegaux, Florence UNSPECIFIED orcid.org/0000-0003-3363-6411 UNSPECIFIED Popa, Alexandru UNSPECIFIED UNSPECIFIED UNSPECIFIED Rabstein, Sylvia UNSPECIFIED UNSPECIFIED UNSPECIFIED Harth, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Pesch, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Fritschi, Lin UNSPECIFIED orcid.org/0000-0002-7692-3560 UNSPECIFIED Glass, Deborah C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heyworth, Jane S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Erren, Thomas C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Castano-Vinyals, Gemma UNSPECIFIED orcid.org/0000-0003-4468-1816 UNSPECIFIED Papantoniou, Kyriaki UNSPECIFIED UNSPECIFIED UNSPECIFIED Espinosa, Ana UNSPECIFIED UNSPECIFIED UNSPECIFIED Kogevinas, Manolis UNSPECIFIED orcid.org/0000-0002-9605-0461 UNSPECIFIED Grundy, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Spinelli, John J. UNSPECIFIED orcid.org/0000-0002-9119-3287 UNSPECIFIED Aronson, Kristan J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Guenel, Pascal UNSPECIFIED orcid.org/0000-0002-8359-518X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-189906
DOI:	10.1007/s10654-018-0368-x
Journal or Publication Title:	Eur. J. Epidemiol.
Volume:	33
Number:	4
Page Range:	S. 369 - 380
Date:	2018
Publisher:	SPRINGER
Place of Publication:	DORDRECHT
ISSN:	1573-7284
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RISK; WOMEN; COHORT; METAANALYSIS Multiple languages Public, Environmental & Occupational Health Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18990