Universität zu Köln

Kreissl, S., Buerkle, C., Ruffer, U., Mehnert, A. and Borchmann, P. (2018). Cancer-related fatigue in Hodgkin's lymphoma. Onkologe, 24 (4). S. 329 - 335. NEW YORK: SPRINGER. ISSN 1433-0415

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Abstract

Cancer-related fatigue (CrF) is among the most frequently observed patient-reported impairments in Hodgkin lymphoma (HL) survivors. The aim of this paper was an evidence-based systematic review of CrF in HL and of current therapeutic options. By a systematic literature search, relevant publications and new developments in the treatment of CrF in current trials were summarized. CrF is prevalent in HL patients even before the onset of chemotherapy and differs significantly between disease stages. In sharp contrast to these different fatigue levels at baseline, fatigue during therapy and more importantly long-term fatigue is remarkably similar across all different stages of HL. Accordingly, we did not observe a negative impact of treatment intensity on the development of long-term fatigue. Fatigue at baseline is a strong predictor of fatigue after treatment. Subtypes of long-term fatigue development result primarily from different baseline fatigue levels. Survivor groups with severe baseline fatigue tend to remain at high fatigue levels during the observation period of 5 years. However, the vast majority of survivors of more advanced stage HL with moderate fatigue at baseline can expect remarkable improvement after successful therapy of HL. The presence of severe fatigue prevents HL patients from social reintegration and thus has major implications for their life as survivors. In the fifth year after therapy, the number of survivors without severe fatigue working or in an educational training program was nearly 30% higher compared to those with severe fatigue. There is evidence that exercise programs and cognitive behaviour therapy help to ameliorate CrF. Further randomized, clinical trials are needed to improve the outcome and quality of life of HL survivors suffering from CrF.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kreissl, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Buerkle, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruffer, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mehnert, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Borchmann, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-190166
DOI:	10.1007/s00761-018-0343-x
Journal or Publication Title:	Onkologe
Volume:	24
Number:	4
Page Range:	S. 329 - 335
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-0415
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIAL; COGNITIVE-BEHAVIOR THERAPY; NON-INFERIORITY TRIAL; DISEASE SURVIVORS; CLINICAL-TRIALS; OPEN-LABEL; EXERCISE; ONCOLOGY; GHSG Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19016