Universität zu Köln

Jiang, Hongzhen, Sitoci-Ficici, Kerim Hakan, Reinshagen, Clemens, Molcanyi, Marek, Zivcak, Jozef, Hudak, Radovan, Laube, Thorsten, Schnabelrauch, Matthias, Weisser, Juergen, Schaefer, Ute, Pinzer, Thomas, Schackert, Gabriele, Zhang, Xifeng, Waehler, Mario, Brautferger, Uta and Rieger, Bernhard ORCID: 0000-0002-0023-884X (2018). Adjustable Polyurethane Foam as Filling Material for a Novel Spondyloplasty: Biomechanics and Biocompatibility. World Neurosurg., 112. S. E848 - 11. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1878-8769

Full text not available from this repository.

Abstract

OBJECTIVE: To investigate the biomechanics and biocompatibility of polyurethane (PU) foam with adjustable stiffness as a filling material for a novel spondyloplasty that is designed to reduce the risk of postoperative adjacent level fractures. METHODS: Sixty individual porcine lumbar vertebrae were randomly split into 4 groups: A, B, C, and D. Group A served as unmodified vertebral body controls. Groups B, C, and D consisted of hollowed vertebral bodies. Vertebrae of groups C and D were filled with adjustable PU foams of different stiffness. The compressive strength and stiffness of vertebrae from groups A-D were recorded and analyzed. 3T3 mouse fibroblasts were cultured with preformed PU foams for 4 days to test biocompatibility. RESULTS: The strength and stiffness of the hollowed groups were lower than in group A. However, the differences were not statistically significant between group A and group C (P > 0.05), and were obviously different be- tween group A and group B or group D < 0.01 and <0.05, respectively). Moreover, the strength and stiffness after filling foams in group C or group D were significantly greater than in group B (P < 0.01 and <0.05, respectively). Live/dead staining of 3T3 cells confirmed the biocompatibility of the PU foam. CONCLUSIONS: The new PU foam shows adaptability regarding its stiffness and excellent cytocompatibility in vitro. The results support the clinical translation of the new PU foams as augmentation material in the development of a novel spondyloplasty.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jiang, Hongzhen UNSPECIFIED UNSPECIFIED UNSPECIFIED Sitoci-Ficici, Kerim Hakan UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinshagen, Clemens UNSPECIFIED UNSPECIFIED UNSPECIFIED Molcanyi, Marek UNSPECIFIED UNSPECIFIED UNSPECIFIED Zivcak, Jozef UNSPECIFIED UNSPECIFIED UNSPECIFIED Hudak, Radovan UNSPECIFIED UNSPECIFIED UNSPECIFIED Laube, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Schnabelrauch, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Weisser, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaefer, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED Pinzer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schackert, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Xifeng UNSPECIFIED UNSPECIFIED UNSPECIFIED Waehler, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Brautferger, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED Rieger, Bernhard UNSPECIFIED orcid.org/0000-0002-0023-884X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-190259
DOI:	10.1016/j.wneu.2018.01.174
Journal or Publication Title:	World Neurosurg.
Volume:	112
Page Range:	S. E848 - 11
Date:	2018
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1878-8769
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VERTEBRAL COMPRESSION FRACTURES; LUMBAR INTERBODY FUSION; BIOACTIVE GLASS; HIDDEN ZONE; VERTEBROPLASTY; CEMENT; AUGMENTATION; KYPHOPLASTY; PMMA; MANAGEMENT Multiple languages Clinical Neurology; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19025