Universität zu Köln

Bettinger, Dominik, Schlabe, Stefan, Pischke, Sven, Mallmann, Michael R., Keyver-Paik, Mignon-Denise, Kuhn, Walther, Strassburg, Christian P., Thimme, Robert and Spengler, Ulrich (2018). Ribavirin in Acute Hepatitis E Infection in Patients with Gynecological Cancer: A Case Series. J. Clin. Transl. Hepatol., 6 (2). S. 237 - 241. SUGAR LAND: XIA & HE PUBLISHING INC. ISSN 2310-8819

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Abstract

Hepatitis E virus infection is usually a self-limited disease. However, during the last years there has been growing evidence for prolonged and chronic infection occurring in patients with immunosuppression. Also patients with malignant and rheumatic diseases have been identified to be at risk for chronic hepatitis E. However, their course and prognosis are not well characterized and there have been no reports of hepatitis E virus infection in patients with gynecological cancer. Here, we report three Caucasian females with breast and ovarian cancers presenting with elevation of aminotransferase levels during anticancer treatment. Although only few or no clinical hints suggested hepatitis E virus infection, the diagnosis of hepatitis E virus infection was confirmed by seroconversion, which might occur with some delay, and/or by polymerase chain reaction. While two patients had a selflimited course, the third patient with a high-risk oncological constellation required ribavirin in order to resume chemotherapy. These cases highlight the need for hepatitis E virus testing in patients with gynecological cancer and elevated aminotransferase levels. Further, these cases show that in selected high-risk patients, ribavirin treatment may be necessary based on the decision of a multidisciplinary team.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bettinger, Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlabe, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Pischke, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann, Michael R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Keyver-Paik, Mignon-Denise UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Walther UNSPECIFIED UNSPECIFIED UNSPECIFIED Strassburg, Christian P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thimme, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Spengler, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-190395
DOI:	10.14218/JCTH.2017.00063
Journal or Publication Title:	J. Clin. Transl. Hepatol.
Volume:	6
Number:	2
Page Range:	S. 237 - 241
Date:	2018
Publisher:	XIA & HE PUBLISHING INC
Place of Publication:	SUGAR LAND
ISSN:	2310-8819
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language E VIRUS-INFECTION; REACTIVATION Multiple languages Gastroenterology & Hepatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19039