Universität zu Köln

Schiltz, Daniel ORCID: 0000-0003-1096-9336, Anker, Alexandra, Ortner, Christine, Tschernitz, Sebastian, Koller, Michael, Klein, Silvan, Felthaus, Oliver, Schreml, Julia, Schreml, Stephan ORCID: 0000-0002-2820-1942 and Prantl, Lukas (2018). Multiple Symmetric Lipomatosis: New Classification System Based on the Largest German Patient Cohort. PRS-GLOB. OPEN, 6 (4). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 2169-7574

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Abstract

Background: Multiple symmetric lipomatosis (MSL) is defined as a disorder of nonencapsulated adipose tissue growth. Its prevalence is indicated as 1: 25,000 and affects, as stated in the literature, mainly Mediterranean males (male: female ratio of 15: 1). Phenotypes are still classified as defined by Donhauser in 1991. We report clinical and phenotypic data of the largest patient cohort investigated in Germany so far. Methods: Forty-five patients diagnosed with MSL at the University Hospital Regensburg between 2007 and 2017 were photographed, clinically examined, and blood samples were taken. Based on the photographs (n = 33), 11 independent observers assessed patients using the Donhauser classification. Furthermore, the bodies of all patients were subdivided into 12 body areas, and the viewers had to indicate all MSL-affected areas per patient. Prevalence was calculated, comorbidities were assessed, and blood samples were analyzed. Results: According to the established Donhauser classification, less than 50% of the patients could be classified. Therefore, based on the constellations of MSL-affected body areas, a new classification that divides phenotypes of MSL into 5 types (Ia, Ib, Ic, II, and III) was set up and was able to cover 100% of our patients. The male to female ratio was found to be 1:2.5 (male: female). Prevalence of MSL in the catchment area was found to be 1:25,000. Hypercholesterinemia and hypothyroidism were frequent comorbidities, and blood analyses were normal besides a hypercholesterinemia. Discussion: The new proposed classification system describes 5 subtypes and allowed to classify all assessed patients. Male to female ratio (1:2.5) contradicted most previous publications.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schiltz, Daniel UNSPECIFIED orcid.org/0000-0003-1096-9336 UNSPECIFIED Anker, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Ortner, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Tschernitz, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Koller, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Silvan UNSPECIFIED UNSPECIFIED UNSPECIFIED Felthaus, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Schreml, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Schreml, Stephan UNSPECIFIED orcid.org/0000-0002-2820-1942 UNSPECIFIED Prantl, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-190481
DOI:	10.1097/GOX.0000000000001722
Journal or Publication Title:	PRS-GLOB. OPEN
Volume:	6
Number:	4
Date:	2018
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	2169-7574
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ADRENERGIC-STIMULATED LIPOLYSIS; OF-THE-LITERATURE; ADIPOSE-TISSUE; MADELUNGS DISEASE; LAUNOIS-BENSAUDE; STEM-CELLS; EXPRESSION; DEFECT; FAT Multiple languages Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19048