Universität zu Köln

Mauler, Joerg, Maudsley, Andrew A., Langen, Karl-Josef ORCID: 0000-0003-1101-5075, Nikoubashman, Omid, Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Sheriff, Sulaiman, Lohmann, Philipp ORCID: 0000-0002-5360-046X, Filss, Christian ORCID: 0000-0002-9927-6335, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Kops, Elena Rota and Shah, N. Jon ORCID: 0000-0002-8151-6169 (2018). Spatial Relationship of Glioma Volume Derived from F-18-FET PET and Volumetric MR Spectroscopy Imaging: A Hybrid PET/MRI Study. J. Nucl. Med., 59 (4). S. 603 - 610. RESTON: SOC NUCLEAR MEDICINE INC. ISSN 1535-5667

Full text not available from this repository.

Abstract

PET imaging of amino acid transport using O-(2-F-18-fluoroethyl)-L-tyrosine (F-18-FET) and proton MR spectroscopy (MRS) imaging of cell turnover measured by the ratio of choline to N-acetyl-aspartate (Cho/NAA) may provide additional information on tumor extent of cerebral gliomas compared with anatomic imaging; however, comparative studies are rare. Methods: In this prospective study, 41 patients (16 women, 25 men; mean age +/- SD, 48 +/- 14 y) with cerebral gliomas (World Health Organization [WHO] grade II: 10 [including 1 patient with 2 lesions], WHO III: 17, WHO IV: 13, without biopsy low-grade: 1, high-grade: 1) were investigated with a hybrid PET/MR scanner. Tumor extent, spatial overlap, and the distance between the corresponding centers of mass in F-18-FET PET and MRS imaging of Cho/NAA, determined by simultaneously acquired, 3-dimensional spatially resolved MRS imaging data, were compared. Results: The average tumor volumes for F-18-FET uptake and increased Cho/NAA were 19 +/- 20 cm(3) (mean +/- SD) and 22 +/- 24 cm(3), respectively, with an overlap of 40% +/- 25% and separation of the centers of mass by 9 +/- 8 mm. None of the parameters showed a significant correlation with tumor grade. Conclusion: F-18-FET uptake and increased Cho/NAA ratio are not always congruent and may represent different properties of glioma metabolism. The relationship to histologic tumor extent needs to be further analyzed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mauler, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Maudsley, Andrew A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED Nikoubashman, Omid UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Sheriff, Sulaiman UNSPECIFIED UNSPECIFIED UNSPECIFIED Lohmann, Philipp UNSPECIFIED orcid.org/0000-0002-5360-046X UNSPECIFIED Filss, Christian UNSPECIFIED orcid.org/0000-0002-9927-6335 UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Kops, Elena Rota UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, N. Jon UNSPECIFIED orcid.org/0000-0002-8151-6169 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-191500
DOI:	10.2967/jnumed.117.196709
Journal or Publication Title:	J. Nucl. Med.
Volume:	59
Number:	4
Page Range:	S. 603 - 610
Date:	2018
Publisher:	SOC NUCLEAR MEDICINE INC
Place of Publication:	RESTON
ISSN:	1535-5667
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MAGNETIC-RESONANCE-SPECTROSCOPY; BRAIN-TUMORS; CEREBRAL GLIOMAS; DIAGNOSTIC PERFORMANCE Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19150