Universität zu Köln

Diao, Yupu, Cui, Liyuan, Chen, Yuqing, Burbridge, Timothy J., Han, Wenqi, Wirth, Brunhilde ORCID: 0000-0003-4051-5191, Sestan, Nenad, Crair, Michael C. and Zhang, Jiayi ORCID: 0000-0002-1575-0723 (2018). Reciprocal Connections Between Cortex and Thalamus Contribute to Retinal Axon Targeting to Dorsal Lateral Geniculate Nucleus. Cereb. Cortex, 28 (4). S. 1168 - 1183. CARY: OXFORD UNIV PRESS INC. ISSN 1460-2199

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Abstract

The dorsal Lateral Geniculate Nucleus (dLGN) is the primary image-forming target of the retina and shares a reciprocal connection with primary visual cortex (V1). Previous studies showed that corticothalamic input is essential for the development of thalamocortical projections, but less is known about the potential role of this reciprocal connection in the development of retinal projections. Here, we show a deficit of retinal innervation in the dLGN around E18.5 in Tra2 beta conditional knockout (cKO) cortexless mice, an age when apoptosis occurs along the thalamocortical tract and in some dLGN neurons. In vivo electrophysiology experiments in the dLGN further confirmed the loss of functional retinal input. Experiments with N-methyl-d-aspartic acid-induced V1 lesion as well as Fezf2 cKO mice confirmed that the disruption of connections between the dLGN and V1 lead to abnormal retinal projections to the dLGN. Interestingly, retinal projections to the ventral Lateral Geniculate Nucleus (vLGN) and Superior Colliculus (SC) were normal in all 3 mice models. Finally, we show that the cortexless mice had worse performance than control mice in a go-no go task with visual cues. Our results provide evidence that the wiring of visual circuit from the retina to the dLGN and V1 thereafter is coordinated at a surprisingly early stage of circuit development.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Diao, Yupu UNSPECIFIED UNSPECIFIED UNSPECIFIED Cui, Liyuan UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, Yuqing UNSPECIFIED UNSPECIFIED UNSPECIFIED Burbridge, Timothy J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Han, Wenqi UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirth, Brunhilde UNSPECIFIED orcid.org/0000-0003-4051-5191 UNSPECIFIED Sestan, Nenad UNSPECIFIED UNSPECIFIED UNSPECIFIED Crair, Michael C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Jiayi UNSPECIFIED orcid.org/0000-0002-1575-0723 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-191614
DOI:	10.1093/cercor/bhx028
Journal or Publication Title:	Cereb. Cortex
Volume:	28
Number:	4
Page Range:	S. 1168 - 1183
Date:	2018
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1460-2199
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VISUAL MAP DEVELOPMENT; CORTICOGENICULATE INNERVATION; RETINOGENICULATE PROJECTIONS; CORTICOTHALAMIC AXONS; SUPERIOR COLLICULUS; MACAQUE MONKEY; GANGLION-CELLS; MOUSE; MICE; INPUTS Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19161