Universität zu Köln

Dragoun, Maxim, Guenther, Thomas, Frias, Corazon, Berkessel, Albrecht ORCID: 0000-0003-0470-7428 and Prokop, Aram (2018). Metal-free salan-type compound induces apoptosis and overcomes multidrug resistance in leukemic and lymphoma cells in vitro. J. Cancer Res. Clin. Oncol., 144 (4). S. 685 - 696. NEW YORK: SPRINGER. ISSN 1432-1335

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Abstract

We report on our preclinical findings of a simple salicylic diamine compound (THG 1213) which has yielded exceptional results as a potential chemotherapeutic drug. THG 1213 is an easy to synthesize chiral and metal-free salan compound. THG 1213 was tested on several leukemia, lymphoma and solid tumor cell lines in vitro. The effects have been studied by LDH release essay, FACS flow cytometry, photometric cell count, immunoblotting, and NMR spectroscopy. THG 1213 selectively inhibits proliferation and induces apoptosis in leukemia, lymphoma and solid tumor cell lines. Necrosis or effects on healthy leucocytes could not be detected. Apoptosis is induced via the intrinsic and extrinsic pathways. The salan THG 1213 overcomes multidrug resistance in tumor cells and acts synergistically with vincristine and daunorubicin. THG 1213 displays remarkable antitumor properties. In particular, the lack of metallic components of THG 1213 could prove to be beneficial in future clinical trials, as metal-containing drugs are known to show severe side effects.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dragoun, Maxim UNSPECIFIED UNSPECIFIED UNSPECIFIED Guenther, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Frias, Corazon UNSPECIFIED UNSPECIFIED UNSPECIFIED Berkessel, Albrecht UNSPECIFIED orcid.org/0000-0003-0470-7428 UNSPECIFIED Prokop, Aram UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-192140
DOI:	10.1007/s00432-018-2592-x
Journal or Publication Title:	J. Cancer Res. Clin. Oncol.
Volume:	144
Number:	4
Page Range:	S. 685 - 696
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1335
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Organic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTITUMOR-ACTIVITY; COMPLEXES; CYTOTOXICITY; TRANSPORTERS; MOLECULES; LIGANDS Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19214