Universität zu Köln

Salamon, Sarah, Santelmann, Hanno, Franklin, Jeremy ORCID: 0000-0003-1536-0925 and Baethge, Christopher (2018). Test-retest reliability of the diagnosis of schizoaffective disorder in childhood and adolescence - A systematic review and meta-analysis. J. Affect. Disord., 230. S. 28 - 34. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1573-2517

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Abstract

Objectives: Reliability of schizoaffective disorder (SAD) diagnoses is low in adults but unclear in children and adolescents (CAD). We estimate the test-retest reliability of SAD and its key differential diagnoses (schizophrenia, bipolar disorder, and unipolar depression). Methods: Systematic literature search of Medline, Embase, and PsycInfo for studies on test-retest reliability of SAD, in CAD. Cohen's kappa was extracted from studies. We performed meta-analysis for kappa, including subgroup and sensitivity analysis (PROSPERO protocol: CRD42013006713). Results: Out of > 4000 records screened, seven studies were included. We estimated kappa values of 0.27 [95%CI: 0.07 0.47] for SAD, 0.56 [0.29; 0.83] for schizophrenia, 0.64 [0.55; 0.74] for bipolar disorder, and 0.66 [0.52; 0.81] for unipolar depression. In 5/7 studies kappa of SAD was lower than that of schizophrenia; similar trends emerged for bipolar disorder (4/5) and unipolar depression (2/3). Estimates of positive agreement of SAD diagnoses supported these results. Limitations: The number of studies and patients included is low. Conclusions: The point-estimate of the test-retest reliability of schizoaffective disorder is only fair, and lower than that of its main differential diagnoses. All kappa values under study were lower in children and adolescents samples than those reported for adults. Clinically, schizoaffective disorder should be diagnosed in strict adherence to the operationalized criteria and ought to be re-evaluated regularly. Should larger studies confirm the insufficient reliability of schizoaffective disorder in children and adolescents, the clinical value of the diagnosis is highly doubtful.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Salamon, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Santelmann, Hanno UNSPECIFIED UNSPECIFIED UNSPECIFIED Franklin, Jeremy UNSPECIFIED orcid.org/0000-0003-1536-0925 UNSPECIFIED Baethge, Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-192251
DOI:	10.1016/j.jad.2017.12.070
Journal or Publication Title:	J. Affect. Disord.
Volume:	230
Page Range:	S. 28 - 34
Date:	2018
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1573-2517
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BIPOLAR DISORDER; ONSET SCHIZOPHRENIA; 1ST-EPISODE PSYCHOSIS; UNIPOLAR DEPRESSION; MOOD DISORDERS; HIGH AGREEMENT; FOLLOW-UP; LOW KAPPA; STABILITY; RECOMMENDATIONS Multiple languages Clinical Neurology; Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19225