Capper, David ORCID: 0000-0003-1945-497X, Jones, David T. W., Sill, Martin ORCID: 0000-0001-7616-7665, Hovestadt, Volker, Schrimpf, Daniel, Sturm, Dominik ORCID: 0000-0003-0250-1696, Koelsche, Christian, Sahm, Felix ORCID: 0000-0001-5441-1962, Chavez, Lukas ORCID: 0000-0002-8718-8848, Reuss, David E., Kratz, Annekathrin, Wefers, Annika K., Huang, Kristin, Pajtler, Kristian W. ORCID: 0000-0002-3562-6121, Schweizer, Leonille, Stichel, Damian, Olar, Adriana, Engel, Nils W., Lindenberg, Kerstin, Harter, Patrick N., Braczynski, Anne K., Plate, Karl H., Dohmen, Hildegard, Garvalov, Boyan K. ORCID: 0000-0003-0013-9064, Coras, Roland, Hoelsken, Annett, Hewer, Ekkehard ORCID: 0000-0002-9128-0364, Bewerunge-Hudler, Melanie, Schick, Matthias, Fischer, Roger, Beschorner, Rudi, Schittenhelm, Jens, Staszewski, Ori ORCID: 0000-0002-0579-6701, Wani, Khalida, Varlet, Pascale, Pages, Melanie, Temming, Petra, Lohmann, Dietmar, Selt, Florian, Witt, Hendrik, Milde, Till, Witt, Olaf, Aronica, Eleonora ORCID: 0000-0002-3542-3770, Giangaspero, Felice ORCID: 0000-0001-5382-2380, Rushing, Elisabeth, Scheurlen, Wolfram, Geisenberger, Christoph, Rodriguez, Fausto J., Becker, Albert, Preusser, Matthias, Haberler, Christine, Bjerkvig, Rolf, Cryan, Jane, Farrell, Michael, Deckert, Martina, Hench, Juergen, Frank, Stephan, Serrano, Jonathan, Kannan, Kasthuri ORCID: 0000-0002-8479-0657, Tsirigos, Aristotelis ORCID: 0000-0002-7512-8477, Brueck, Wolfgang, Hofer, Silvia, Brehmer, Stefanie, Seiz-Rosenhagen, Marcel, Haenggi, Daniel, Hans, Volkmar, Rozsnoki, Stephanie, Hansford, Jordan R., Kohlhof, Patricia, Kristensen, Bjarne W., Lechner, Matt, Lopes, Beatriz, Mawrin, Christian, Ketter, Ralf, Kulozik, Andreas, Khatib, Ziad, Heppner, Frank ORCID: 0000-0001-9816-8917, Koch, Arend, Jouvet, Anne, Keohane, Catherine, Muehleisen, Helmut, Mueller, Wolf, Pohl, Ute, Prinz, Marco, Benner, Axel, Zapatka, Marc ORCID: 0000-0001-8287-5967, Gottardo, Nicholas G., Driever, Pablo Hernaiz, Kramm, Christof M., Mueller, Hermann L., Rutkowski, Stefan, von Hoff, Katja, Fruehwald, Michael C., Gnekow, Astrid, Fleischhack, Gudrun, Tippelt, Stephan, Calaminus, Gabriele, Monoranu, Camelia-Maria, Perry, Arie, Jones, Chris ORCID: 0000-0001-8118-2296, Jacques, Thomas S., Radlwimmer, Bernhard, Gessi, Marco, Pietsch, Torsten, Schramm, Johannes, Schackert, Gabriele, Westphal, Manfred, Reifenberger, Guido, Wesseling, Pieter, Weller, Michael ORCID: 0000-0002-1748-174X, Collins, Vincent Peter, Bluemcke, Ingmar, Bendszus, Martin, Debus, Juergen, Huang, Annie, Jabado, Nada, Northcott, Paul A., Paulus, Werner, Gajjar, Amar, Robinson, Giles W., Taylor, Michael D., Jaunmuktane, Zane ORCID: 0000-0001-7738-8881, Ryzhova, Marina ORCID: 0000-0001-7206-6365, Platten, Michael ORCID: 0000-0002-4746-887X, Unterberg, Andreas, Wick, Wolfgang ORCID: 0000-0002-6171-634X, Karajannis, Matthias A., Mittelbronn, Michel, Acker, Till, Hartmann, Christian, Aldape, Kenneth, Schueller, Ulrich, Buslei, Rolf, Lichter, Peter, Kool, Marcel, Herold-Mende, Christel, Ellison, David W., Hasselblatt, Martin, Snuderl, Matija ORCID: 0000-0003-0752-0917, Brandner, Sebastian, Korshunov, Andrey ORCID: 0000-0002-5257-3623, von Deimling, Andreas ORCID: 0000-0002-5863-540X and Pfister, Stefan M. (2018). DNA methylation-based classification of central nervous system tumours. Nature, 555 (7697). S. 469 - 495. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4687

Full text not available from this repository.

Abstract

Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challengingwith substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Capper, DavidUNSPECIFIEDorcid.org/0000-0003-1945-497XUNSPECIFIED
Jones, David T. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sill, MartinUNSPECIFIEDorcid.org/0000-0001-7616-7665UNSPECIFIED
Hovestadt, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schrimpf, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sturm, DominikUNSPECIFIEDorcid.org/0000-0003-0250-1696UNSPECIFIED
Koelsche, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sahm, FelixUNSPECIFIEDorcid.org/0000-0001-5441-1962UNSPECIFIED
Chavez, LukasUNSPECIFIEDorcid.org/0000-0002-8718-8848UNSPECIFIED
Reuss, David E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kratz, AnnekathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wefers, Annika K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huang, KristinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pajtler, Kristian W.UNSPECIFIEDorcid.org/0000-0002-3562-6121UNSPECIFIED
Schweizer, LeonilleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stichel, DamianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olar, AdrianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engel, Nils W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindenberg, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harter, Patrick N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braczynski, Anne K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plate, Karl H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dohmen, HildegardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garvalov, Boyan K.UNSPECIFIEDorcid.org/0000-0003-0013-9064UNSPECIFIED
Coras, RolandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoelsken, AnnettUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hewer, EkkehardUNSPECIFIEDorcid.org/0000-0002-9128-0364UNSPECIFIED
Bewerunge-Hudler, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schick, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, RogerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beschorner, RudiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schittenhelm, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Staszewski, OriUNSPECIFIEDorcid.org/0000-0002-0579-6701UNSPECIFIED
Wani, KhalidaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Varlet, PascaleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pages, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Temming, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lohmann, DietmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Selt, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witt, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milde, TillUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witt, OlafUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aronica, EleonoraUNSPECIFIEDorcid.org/0000-0002-3542-3770UNSPECIFIED
Giangaspero, FeliceUNSPECIFIEDorcid.org/0000-0001-5382-2380UNSPECIFIED
Rushing, ElisabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheurlen, WolframUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geisenberger, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez, Fausto J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becker, AlbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Preusser, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haberler, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bjerkvig, RolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cryan, JaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farrell, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deckert, MartinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hench, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frank, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Serrano, JonathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kannan, KasthuriUNSPECIFIEDorcid.org/0000-0002-8479-0657UNSPECIFIED
Tsirigos, AristotelisUNSPECIFIEDorcid.org/0000-0002-7512-8477UNSPECIFIED
Brueck, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hofer, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brehmer, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seiz-Rosenhagen, MarcelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haenggi, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hans, VolkmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rozsnoki, StephanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansford, Jordan R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kohlhof, PatriciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kristensen, Bjarne W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lechner, MattUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopes, BeatrizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mawrin, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ketter, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kulozik, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khatib, ZiadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heppner, FrankUNSPECIFIEDorcid.org/0000-0001-9816-8917UNSPECIFIED
Koch, ArendUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jouvet, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keohane, CatherineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muehleisen, HelmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, WolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pohl, UteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prinz, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benner, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zapatka, MarcUNSPECIFIEDorcid.org/0000-0001-8287-5967UNSPECIFIED
Gottardo, Nicholas G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Driever, Pablo HernaizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kramm, Christof M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, Hermann L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rutkowski, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Hoff, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fruehwald, Michael C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gnekow, AstridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fleischhack, GudrunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tippelt, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calaminus, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monoranu, Camelia-MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perry, ArieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jones, ChrisUNSPECIFIEDorcid.org/0000-0001-8118-2296UNSPECIFIED
Jacques, Thomas S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Radlwimmer, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gessi, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pietsch, TorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schramm, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schackert, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Westphal, ManfredUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reifenberger, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wesseling, PieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weller, MichaelUNSPECIFIEDorcid.org/0000-0002-1748-174XUNSPECIFIED
Collins, Vincent PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bluemcke, IngmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bendszus, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Debus, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huang, AnnieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jabado, NadaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Northcott, Paul A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paulus, WernerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gajjar, AmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robinson, Giles W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taylor, Michael D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaunmuktane, ZaneUNSPECIFIEDorcid.org/0000-0001-7738-8881UNSPECIFIED
Ryzhova, MarinaUNSPECIFIEDorcid.org/0000-0001-7206-6365UNSPECIFIED
Platten, MichaelUNSPECIFIEDorcid.org/0000-0002-4746-887XUNSPECIFIED
Unterberg, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wick, WolfgangUNSPECIFIEDorcid.org/0000-0002-6171-634XUNSPECIFIED
Karajannis, Matthias A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mittelbronn, MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Acker, TillUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartmann, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aldape, KennethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schueller, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buslei, RolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lichter, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kool, MarcelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herold-Mende, ChristelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ellison, David W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hasselblatt, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Snuderl, MatijaUNSPECIFIEDorcid.org/0000-0003-0752-0917UNSPECIFIED
Brandner, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Korshunov, AndreyUNSPECIFIEDorcid.org/0000-0002-5257-3623UNSPECIFIED
von Deimling, AndreasUNSPECIFIEDorcid.org/0000-0002-5863-540XUNSPECIFIED
Pfister, Stefan M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-192489
DOI: 10.1038/nature26000
Journal or Publication Title: Nature
Volume: 555
Number: 7697
Page Range: S. 469 - 495
Date: 2018
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1476-4687
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CLASS PROBABILITY ESTIMATION; MOLECULAR CLASSIFICATION; MEDULLOBLASTOMA; MULTICENTER; EXPRESSION; SUBGROUPS; COMPRISE; SUBSETS; GLIOMASMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19248

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item